5-(2,3-dimethoxyphenyl)-ε-caprolactam

Base Information

Chemical Name:5-(2,3-dimethoxyphenyl)-ε-caprolactam
CAS No.:76679-05-5
Molecular Formula:C₁₄H₁₉NO₃
Molecular Weight:249.31
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2,3-dimethoxyphenyl)-ε-caprolactam

Chemical Property:

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Technology Process of 5-(2,3-dimethoxyphenyl)-ε-caprolactam

There total 10 articles about 5-(2,3-dimethoxyphenyl)-ε-caprolactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76679-04-4
4-(2,3-dimethoxyphenyl)cyclohexanone oxime

: 76679-05-5
5-(2,3-dimethoxyphenyl)-ε-caprolactam

Guidance literature:: With PPA; at 100 - 110 ℃; for 0.166667h; Yield given;
DOI:10.1248/cpb.28.2862

Reference yield:

: 4468-57-9
2-(2,3-dimethoxyphenyl)acetonitrile

: 76679-05-5
5-(2,3-dimethoxyphenyl)-ε-caprolactam

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / KOH / methanol; 2-methyl-propan-2-ol / 2 h / 30 - 40 °C

2: 93 percent / HCl / 1.) reflux, 7 h, 2.) reflux, 5 h,

3: 1.) NaH, 2.) HCl, / 1.) toluene, reflux, 3 h, 2.) AcOH, H₂O, reflux, 2.5 h,

4: 99 percent / p-TsOH / toluene / 4 h / Heating

5: 92 percent / Na / toluene; ethanol / 1.) reflux, 2.) RT; 1 h,

6: 93 percent / cc HCl / H₂O; ethanol / 2.5 h / Heating

7: 81 percent / hydroxylamine*HCl / pyridine / 1 h / 110 °C

8: PPA / 0.17 h / 100 - 110 °C

With hydrogenchloride; potassium hydroxide; hydroxylamine hydrochloride; sodium; sodium hydride; toluene-4-sulfonic acid; In pyridine; methanol; ethanol; water; toluene; tert-butyl alcohol;
DOI:10.1248/cpb.28.2862

Reference yield:

: 26709-74-0
1-(2,3-dimethoxyphenyl)-4-oxocyclohexanecarbonitrile

: 76679-05-5
5-(2,3-dimethoxyphenyl)-ε-caprolactam

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / p-TsOH / toluene / 4 h / Heating

2: 92 percent / Na / toluene; ethanol / 1.) reflux, 2.) RT; 1 h,

3: 93 percent / cc HCl / H₂O; ethanol / 2.5 h / Heating

4: 81 percent / hydroxylamine*HCl / pyridine / 1 h / 110 °C

5: PPA / 0.17 h / 100 - 110 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium; toluene-4-sulfonic acid; In pyridine; ethanol; water; toluene;
DOI:10.1248/cpb.28.2862