4H-Pyrrolo[3,2-c]pyridin-4-one, 2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-, (7S)-

Base Information

• Chemical Name: 4H-Pyrrolo[3,2-c]pyridin-4-one, 2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-, (7S)-
• CAS No.: 1057097-72-9
• Molecular Formula: C₁₃H₁₄FN₅O
• Molecular Weight: 275.285

Synonyms:(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;4H-Pyrrolo[3,2-c]pyridin-4-one, 2-(2-aMino-4-pyriMidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-, (7S)-

Chemical Property of 4H-Pyrrolo[3,2-c]pyridin-4-one, 2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-, (7S)-

Chemical Property:

• PSA: 100.91000
• LogP: 1.18100

Purity/Quality:

99% ^*data from raw suppliers

(7S)-2-(2-AMINO-4-PYRIMIDINYL)-7-(2-FLUOROETHYL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO-[3,2-C]PYRIDIN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Pyrrolo[3,2-c]pyridin-4-one, 2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-, (7S)-

There total 5 articles about 4H-Pyrrolo[3,2-c]pyridin-4-one, 2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-, (7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H22FN5O3 → 2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one (942297-39-4,1057097-72-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jm800977q

Reference yield:

5-(2-fluoroethyl)piperidine-2,4-dione (942297-73-6) + 2-Amino-4-bromoacetylpyrimidine (106157-91-9) → 2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one (942297-39-4,1057097-72-9)

Guidance literature:

With ammonium acetate; In ethanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm800977q

Reference yield:

2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one (942297-39-4,1057097-72-9) → (R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one (942297-39-4,1057097-72-9) + (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one (942297-39-4,1057097-72-9)

Guidance literature:

Purification / work up; Resolution of racemate;

upstream raw materials:

5-(2-fluoroethyl)piperidine-2,4-dione

2-Amino-4-bromoacetylpyrimidine

2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

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