4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Base Information

Chemical Name:4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
CAS No.:876708-03-1
Molecular Formula:C₉H₁₂N₆O₅
Molecular Weight:284.231
Hs Code.:
ChEMBL ID:CHEMBL513181
DSSTox Substance ID:DTXSID30467889
Nikkaji Number:J2.560.803H
Wikidata:Q82294972
Mol file:876708-03-1.mol

Synonyms:RO-9187;876708-03-1;RO 9187;4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;CHEMBL513181;SCHEMBL13471886;DTXSID30467889;BKB70803;EX-A6754;AKOS040742565;CS-0954;NCGC00378981-01;NCGC00378981-02;CID 11514721;HY-10870;MS-24034;4-amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;4-Amino-1-(5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one;4-amino-1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one;4-amino-1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

Suppliers and Price of 4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
RO-9187 >98%
10 mg
$ 212.80

DC Chemicals
RO-9187 >98%
50 mg
$ 579.20

ChemScene
RO-9187 ≥98.0%
10mg
$ 319.00

ChemScene
RO-9187 ≥98.0%
5mg
$ 244.00

ChemScene
RO-9187 ≥98.0%
50mg
$ 869.00

Biorbyt Ltd
RO-9187
50 mg
$ 882.30

Biorbyt Ltd
RO-9187
10 mg
$ 440.30

Total 12 raw suppliers

Chemical Property of 4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Chemical Property:

Melting Point:188.0-189.0℃
PSA：180.58000
LogP:-1.89104
XLogP3:-1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:284.08691750
Heavy Atom Count:20
Complexity:529

Purity/Quality:

99%, ^*data from raw suppliers

RO-9187 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Isomeric SMILES:C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)O

Technology Process of 4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

There total 3 articles about 4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₃₇H₂₈N₆O₉

: 876708-03-1
4'-azidoarabinocytidine

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 14h;

Reference yield: 26.0%

: 876708-01-9
1-(4'-azido-β-D-arabinofuranosyl)uracil

: 876708-03-1
4'-azidoarabinocytidine

Guidance literature:: 1-(4'-azido-β-D-arabinofuranosyl)uracil; With pyridine; dmap; acetic anhydride; at 20 ℃; for 20h; Inert atmosphere;

With 1,2,3-triazole; triethylamine; trichlorophosphate; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

With ammonium hydroxide; In 1,4-dioxane; for 12h;
DOI:10.1021/jm800981y