1-Piperazineacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo-

Base Information

Chemical Name:1-Piperazineacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo-
CAS No.:549506-52-7
Molecular Formula:C₂₁H₂₆ClN₇O₅S₂
Molecular Weight:556.066
Hs Code.:

Synonyms:1-PiperazineacetaMide, N-[(1S)-4-[(aMinoiMinoMethyl)aMino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo-;2-[4-(4-chlorophenyl)sulfonyl-2-oxopiperazin-1-yl]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]acetamide

Suppliers and Price of 1-Piperazineacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-[(1S)-4-[(AMINOIMINOMETHYL)AMINO]-1-(2-THIAZOLYLCARBONYL)BUTYL]-4-[(4-CHLOROPHENYL)SULFONYL]-2-OXO-1-PIPERAZINE ACETAMIDE 95.00%
5MG
$ 495.98

Total 2 raw suppliers

Chemical Property of 1-Piperazineacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo-

Chemical Property:

PSA：218.76000
LogP:3.24820

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S)-4-[(AMINOIMINOMETHYL)AMINO]-1-(2-THIAZOLYLCARBONYL)BUTYL]-4-[(4-CHLOROPHENYL)SULFONYL]-2-OXO-1-PIPERAZINE ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperazineacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo-

There total 6 articles about 1-Piperazineacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-thiazolylcarbonyl)butyl]-4-[(4-chlorophenyl)sulfonyl]-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5657-17-0
ethylenediaminediacetic acid

: 549506-52-7
2-[4-(4-chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. HCl / 4 h / Heating

2: aq. Na₂CO₃ / dioxane

3: BOP; DIEA / dimethylformamide

4: TFA / CH₂Cl₂

5: DIEA / dimethylformamide / -78 - 0 °C

6: HF

With hydrogenchloride; hydrogen fluoride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)01037-5

Reference yield:

: 24860-46-6
2-(2-oxopiperazino)acetic acid

: 549506-52-7
2-[4-(4-chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. Na₂CO₃ / dioxane

2: BOP; DIEA / dimethylformamide

3: TFA / CH₂Cl₂

4: DIEA / dimethylformamide / -78 - 0 °C

5: HF

With hydrogen fluoride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)01037-5

Reference yield:

: 549506-47-0
2-(4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl)acetic acid

: 549506-52-7
2-[4-(4-chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: BOP; DIEA / dimethylformamide

2: TFA / CH₂Cl₂

3: DIEA / dimethylformamide / -78 - 0 °C

4: HF

With hydrogen fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)01037-5