hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt

Base Information

• Chemical Name: hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt
• CAS No.: 1350364-05-4
• Molecular Formula: C₇H₉N*C₁₂H₂₄O₅Si
• Molecular Weight: 383.56
• Mol file: 1350364-05-4.mol

Synonyms:

Chemical Property of hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt

There total 7 articles about hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hydrogen (3R)-1-methyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate (109744-49-2) + benzylamine (100-46-9) → hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt (1350364-05-4)

Guidance literature:

In hexane; for 3.33333h;

Reference yield:

3-(tert-butyldimethylsilyloxy)glutaric anhydride (91424-40-7) → hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt (1350364-05-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium; triphenylmethane; (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol / toluene; hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 3 h

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

3.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice

3.3: pH 6.5

4.1: hexane / 3.33 h

With n-butyllithium; triphenylmethane; hydrogen; sodium methylate; (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol; palladium 10% on activated carbon; In tetrahydrofuran; hexane; ethyl acetate; toluene;

Reference yield:

(3R)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1- ester → hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate benzylamine salt (1350364-05-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

2.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice

2.3: pH 6.5

3.1: hexane / 3.33 h

With hydrogen; sodium methylate; palladium 10% on activated carbon; In hexane; ethyl acetate;

upstream raw materials:

Hydrogen (3R)-1-methyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate

benzylamine

3-(tert-butyldimethylsilyloxy)glutaric anhydride

hydrogen (3R)-1-methyl 3-[(tert-butyldimethylsilyl)-oxy]pentanedioate cyclohexylamine salt