Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]-

Base Information

Chemical Name:Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]-
CAS No.:733734-61-7
Molecular Formula:C₂₀H₂₂BrF₃N₂O₅S
Molecular Weight:539.37
Hs Code.:
Mol file:733734-61-7.mol

Synonyms:SB 706375;2-bromo-4,5-dimethoxy-N-[3-[(3R)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)phenyl]benzenesulfonamide;2-Bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide;BenzenesulfonaMide, 2-broMo-4,5-diMethoxy-N-[3-[[(3R)-1-Methyl-3-pyrrolidinyl]oxy]-4-(trifluoroMethyl)phenyl]-

Suppliers and Price of Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SB706375
100mg
$ 1210.00

Tocris
SB706375 ≥98%(HPLC)
50
$ 673.00

Tocris
SB706375 ≥98%(HPLC)
10
$ 185.00

Medical Isotopes, Inc.
SB706375
50 mg
$ 1225.00

ApexBio Technology
SB706375
50mg
$ 1305.00

ApexBio Technology
SB706375
10mg
$ 322.00

American Custom Chemicals Corporation
2-BROMO-4,5-DIMETHOXY-N-[3-[[(3R)-1-METHYL-3-PYRROLIDINYL]OXY]-4-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE 95.00%
5MG
$ 502.54

Total 2 raw suppliers

Chemical Property of Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]-

Chemical Property:

PSA：85.48000
LogP:5.46050

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

SB706375 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses SB 706375 has high affinity towards the non-peptide antagonist of the urotensin-II (UT). This includes high affinity towards mammalian UT receptors which include human, mouse and rat.

Technology Process of Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]-

There total 4 articles about Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₅F₃N₂O

: 51072-64-1
2-bromo-4,5-dimethoxybenzene-1-sulfonyl chloride

: 1428555-12-7,733734-61-7
C₂₀H₂₂BrF₃N₂O₅S

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2013.01.105

Reference yield:

: 69411-67-2
2-fluoro-4-nitro-1-(trifluoromethyl)benzene

: 1428555-12-7,733734-61-7
C₂₀H₂₂BrF₃N₂O₅S

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 48 h / 0 - 20 °C

2: 10% Pt/activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 2068.65 Torr

3: pyridine / 1,2-dichloro-ethane / 16 h / 20 °C

With pyridine; 10% Pt/activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2013.01.105

Reference yield:

: 104641-59-0,99445-21-3
(3S)-1-methylpyrrolidin-3-ol

: 1428555-12-7,733734-61-7
C₂₀H₂₂BrF₃N₂O₅S

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 48 h / 0 - 20 °C

2: 10% Pt/activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 2068.65 Torr

3: pyridine / 1,2-dichloro-ethane / 16 h / 20 °C

With pyridine; 10% Pt/activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2013.01.105