Phenol, 4-methyl-3-[[6-(methylsulfonyl)-7-[2-(4-morpholinylmethyl)-4-thiazolyl]-4-quinolinyl]amino]-

Base Information

• Chemical Name: Phenol, 4-methyl-3-[[6-(methylsulfonyl)-7-[2-(4-morpholinylmethyl)-4-thiazolyl]-4-quinolinyl]amino]-
• CAS No.: 955879-81-9
• Molecular Formula: C₂₅H₂₆N₄O₄S₂
• Molecular Weight: 510.638
• Mol file: 955879-81-9.mol

Synonyms:RET INHIBITOR;4-methyl-3-[[6-(methylsulfonyl)-7-[2-(4-morpholinylmethyl)-4-thiazolyl]-4-quinolinyl]amino]phenol;Phenol, 4-Methyl-3-[[6-(Methylsulfonyl)-7-[2-(4-MorpholinylMethyl)-4-thiazolyl]-4-quinolinyl]aMino]-

Chemical Property of Phenol, 4-methyl-3-[[6-(methylsulfonyl)-7-[2-(4-morpholinylmethyl)-4-thiazolyl]-4-quinolinyl]amino]-

Chemical Property:

• Boiling Point: 734.1±60.0 °C(Predicted)
• PKA: 9.89±0.18(Predicted)
• PSA: 141.27000
• Density: 1.400±0.06 g/cm3(Predicted)
• LogP: 5.44330

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-3-((6-(methylsulfonyl)-7-(2-(morpholinomethyl)thiazol-4-yl)quinolin-4-yl)amino)phenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 4-methyl-3-[[6-(methylsulfonyl)-7-[2-(4-morpholinylmethyl)-4-thiazolyl]-4-quinolinyl]amino]-

There total 2 articles about Phenol, 4-methyl-3-[[6-(methylsulfonyl)-7-[2-(4-morpholinylmethyl)-4-thiazolyl]-4-quinolinyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

C18H18ClN3O3S2 (1062589-98-3) + 3-amino-4-methylphenol (2836-00-2) → C25H26N4O4S2 (955879-81-9)

Guidance literature:

In butan-1-ol; at 120 ℃; for 19h;

Reference yield:

morpholine (110-91-8,99108-56-2) + C21H17N3O4S2 → C25H26N4O4S2 (955879-81-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid;

DOI:10.1016/j.bmcl.2007.07.104

upstream raw materials:

morpholine

C₁₈H₁₈ClN₃O₃S₂

3-amino-4-methylphenol

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