2836-00-2

Basic information

• Product Name: 3-Amino-4-methylphenol
• Synonyms: 3-amino-p-cresol;3-AMINO-4-METHYLPHENOL;5-Hydroxy-o-toluidine;2-AMINO-4-HYDROXYTOLUENE;5-Hydroxy-2-methylaniline;m-Amino-p-cresol;Phenol, 3-amino-4-methyl-;3-azanyl-4-methyl-phenol
• CAS NO: 2836-00-2
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• EINECS: 220-622-8
• Product Categories: pharmacetical;Phenol&Thiophenol&Mercaptan
• Mol File: 2836-00-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 156-157°C
• Boiling Point: 229.26°C (rough estimate)
• Flash Point: 119.596 °C
• Appearance: crystals
• Density: 1.0877 (rough estimate)
• Vapor Pressure: 0.00328mmHg at 25°C
• Refractive Index: 1.5706 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.32±0.18(Predicted)
• CAS DataBase Reference: 3-Amino-4-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methylphenol(2836-00-2)
• EPA Substance Registry System: 3-Amino-4-methylphenol(2836-00-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2836-00-2(Hazardous Substances Data)

Usage

General Description

Crystals.

Air & Water Reactions

3-Amino-4-methylphenol may be sensitive to prolonged exposure to air.

Reactivity Profile

3-Amino-4-methylphenol reacts with strong oxidizing agents.

Fire Hazard

Flash point data for 3-Amino-4-methylphenol are not available. 3-Amino-4-methylphenol is probably combustible.

InChI:InChI=1/C7H9NO/c1-5-2-3-6(9)4-7(5)8/h2-4,9H,8H2,1H3

Upstream product

• 50868-72-9 5-methoxy-o-toluidine 
• 120-37-6 3-ethylamino-4-methylphenol 
• 621-02-3 di-p-tolyl carbonate 
• 7647-01-0 hydrogenchloride 
• 95-53-4 o-toluidine 
• 5434-30-0 N-(5-amino-2-methylphenyl)acetamide 
• 2042-14-0 4-methyl-5-nitrophenol 
• 119-32-4 4-Methyl-3-nitroanilin 
• 2879-79-0 N-(2-methyl-5-nitrophenyl)acetamide 

Downstream Products

• 1236218-23-7 isobutyric acid 3-isobutyrylamino-4-methyl-phenyl ester 
• 861008-27-7 5-(2-methoxyethoxy)-2-methylaniline 

Relevant articles and documents

Minimization of Back-Electron Transfer Enables the Elusive sp3 C?H Functionalization of Secondary Anilines

Anilines are some of the most used class of substrates for application in photoinduced electron transfer. N,N-Dialkyl-derivatives enable radical generation α to the N-atom by oxidation followed by deprotonation. This approach is however elusive to monosubstituted anilines owing to fast back-electron transfer (BET). Here we demonstrate that BET can be minimised by using photoredox catalysis in the presence of an exogenous alkylamine. This approach synergistically aids aniline SET oxidation and then accelerates the following deprotonation. In this way, the generation of α-anilinoalkyl radicals is now possible and these species can be used in a general sense to achieve divergent sp3 C?H functionalization.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

Nitrogen-doped graphene-activated metallic nanoparticle-incorporated ordered mesoporous carbon nanocomposites for the hydrogenation of nitroarenes

Herein, nanoscale metallic nanoparticle-incorporated ordered mesoporous carbon catalysts activated by nitrogen-doped graphene (NGr) were fabricated via an efficient multi-component co-assembly of a phenolic resin, nitrate, acetylacetone, the nitrogen-containing compound 1,10-phenanthroline, and Pluronic F127, followed by carbonization. The obtained well-dispersed nitrogen-doped graphene-activated transition metal nanocatalysts possess a 2-D hexagonally arranged pore structure with a high surface area (～500 m2 g-1) and uniform pore size (～4.0 nm) and show excellent activity for the selective hydrogenation-reduction of substituted nitroarenes to anilines in an environmentally friendly aqueous solution. The high catalytic performance and durability is attributed to the synergistic effects among the components, the unique structure of the nitrogen-doped graphene layer-coated metallic nanoparticles, and electronic activation of the doped nitrogen.