Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-4-(methylsulfonyl)-

Base Information

• Chemical Name: Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-4-(methylsulfonyl)-
• CAS No.: 894803-86-2
• Molecular Formula: C₁₉H₂₂N₄O₆S
• Molecular Weight: 434.473
• Mol file: 894803-86-2.mol

Synonyms:N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide;BenzeneacetaMide, N-(4-aMino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-diMethoxy-4-(Methylsulfonyl)-

Chemical Property of Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-4-(methylsulfonyl)-

Chemical Property:

• PSA: 165.24000
• LogP: 2.61998

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-4-(methylsulfonyl)-

There total 8 articles about Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-4-(methylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-methanesulfonyl-2,5-dimethoxyphenyl)acetyl chloride (894803-66-8) + 4,6-Diamino-2-ethoxy-3-pyridincarbonitril (32410-05-2) → N-(4-amino-5-cyano-6-ethoxy-pyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxy-phenyl)-acetamide (894803-86-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm060199b

Reference yield:

2-(2,5-dimethoxy-4-methylsulfanylphenyl)ethanol (894803-67-9) → N-(4-amino-5-cyano-6-ethoxy-pyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxy-phenyl)-acetamide (894803-86-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / aq. H₂O₂; TFA / 4 h / 20 °C

2: 32 percent / aq. H₂CrO₄ / acetone / 3 h

3: SOCl₂ / 0.33 h / Heating

4: 34 mg / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; thionyl chloride; dihydrogen peroxide; chromic acid; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1021/jm060199b

Reference yield:

2-(4-methanesulfonyl-2,5-dimethoxyphenyl)ethanol (904311-61-1) → N-(4-amino-5-cyano-6-ethoxy-pyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxy-phenyl)-acetamide (894803-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / aq. H₂CrO₄ / acetone / 3 h

2: SOCl₂ / 0.33 h / Heating

3: 34 mg / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; thionyl chloride; chromic acid; In dichloromethane; acetone;

DOI:10.1021/jm060199b

upstream raw materials:

(4-methanesulfonyl-2,5-dimethoxyphenyl)acetyl chloride

4,6-Diamino-2-ethoxy-3-pyridincarbonitril

2-(2,5-dimethoxy-4-methylsulfanylphenyl)ethanol

2-(4-methanesulfonyl-2,5-dimethoxyphenyl)ethanol