5H-Pyrrolo[1,2-a]imidazole-5-methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylamino)-4-pyrimidinyl]-, (5S)-

Base Information

Chemical Name:5H-Pyrrolo[1,2-a]imidazole-5-methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylamino)-4-pyrimidinyl]-, (5S)-
CAS No.:869287-24-1
Molecular Formula:C₂₀H₂₂FN₅O
Molecular Weight:367.426
Hs Code.:

Synonyms:[(5S)-2-(4-fluorophenyl)-3-[2-(propylamino)pyrimidin-4-yl]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]methanol;5H-Pyrrolo[1,2-a]iMidazole-5-Methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylaMino)-4-pyriMidinyl]-, (5S)-

Suppliers and Price of 5H-Pyrrolo[1,2-a]imidazole-5-methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylamino)-4-pyrimidinyl]-, (5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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American Custom Chemicals Corporation
(5S)-2-(4-FLUOROPHENYL)-6,7-DIHYDRO-3-[2-(PROPYLAMINO)-4-PYRIMIDINYL]-5H-PYRROLO-[1,2-]IMIDAZOLE-5-METHANOL 95.00%
5MG
$ 497.71

Total 1 raw suppliers

Chemical Property of 5H-Pyrrolo[1,2-a]imidazole-5-methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylamino)-4-pyrimidinyl]-, (5S)-

Chemical Property:

PSA：79.09000
LogP:2.86960

Purity/Quality:: (5S)-2-(4-FLUOROPHENYL)-6,7-DIHYDRO-3-[2-(PROPYLAMINO)-4-PYRIMIDINYL]-5H-PYRROLO-[1,2-]IMIDAZOLE-5-METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5H-Pyrrolo[1,2-a]imidazole-5-methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylamino)-4-pyrimidinyl]-, (5S)-

There total 32 articles about 5H-Pyrrolo[1,2-a]imidazole-5-methanol, 2-(4-fluorophenyl)-6,7-dihydro-3-[2-(propylamino)-4-pyrimidinyl]-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 926660-11-9
{4-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-fluoro-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine

: 869287-24-1
[2-(4-fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ja0676004

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 869287-24-1
[2-(4-fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: imidazole / dimethylformamide / 2 h / 20 °C

2.1: Lawesson's reagent / tetrahydrofuran / 2 h / 20 °C

3.1: CH₂Cl₂ / 5 h / 20 °C

4.1: NH₄Cl / methanol / 3.5 h / 50 °C

5.1: ethyl acetate / 16 h / 20 °C

6.1: HBr; AcOH / aq. ethanol / 5.5 h / Heating

7.1: TBAF / tetrahydrofuran / 1 h / 0 - 20 °C

8.1: 99 percent / aq. NaOH; n-Bu₄NHSO₄ / 12 h / 20 °C

9.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

9.2: Bu₃SnI

9.3: 48 percent / Pd(PPh₃)4 / dimethylformamide / 96 h / 80 °C

10.1: H₂O₂; AcOH / 48 h

10.2: 36 percent / 20 °C

11.1: aq. HCl / methanol / 125 °C

With Lawessons reagent; 1H-imidazole; hydrogenchloride; sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen bromide; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 9.3: Stille coupling;
DOI:10.1016/j.bmcl.2005.07.076

Reference yield:

: 926659-97-4
(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

: 869287-24-1
[2-(4-fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / CH₂Cl₂ / 0.25 h / -78 °C

2: 85 percent / triphenylphosphine; LiCl; CuI / Pd₂(dba)2*CHCl₃ / dioxane / 5.5 h / 170 °C

3: 79 percent / oxone / tetrahydrofuran; H₂O / 5 h / 20 °C

4: 78 percent / 8 h / 20 °C

5: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With Oxone; copper(l) iodide; tetrabutyl ammonium fluoride; bromine; triphenylphosphine; lithium chloride; Pd₂(dibenzylideneacetone)2*CHCl₃; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ja0676004