C₁₉H₁₅F₃N₄

Base Information

Chemical Name:C₁₉H₁₅F₃N₄
CAS No.:1620328-43-9
Molecular Formula:C₁₉H₁₅F₃N₄
Molecular Weight:356.35
Hs Code.:

C<sub>19</sub>H<sub>15</sub>F<sub>3</sub>N<sub>4</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₉H₁₅F₃N₄

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Technology Process of C₁₉H₁₅F₃N₄

There total 12 articles about C₁₉H₁₅F₃N₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620328-23-5
C₃₈H₂₉F₃N₄

: 1620328-43-9
C₁₉H₁₅F₃N₄

Guidance literature:: With N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1160502-31-7
4-iodo-3-(trifluoromethyl)-1-tritylpyrazolo[5,4-b]pyridine

: 1620328-43-9
C₁₉H₁₅F₃N₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; 1,4-di(diphenylphosphino)-butane; tert-butylamine; propyl cyanide / water / 16 h / 120 °C

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation

2.2: 5 h / 20 °C / 760.05 Torr

3.1: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With propyl cyanide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; palladium diacetate; tert-butylamine; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 1.1: |Suzuki Coupling / 2.1: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1435-51-4
1,3-dibromo-5-fluorobenzene

: 1620328-43-9
C₁₉H₁₅F₃N₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 24 h / 120 °C

2.1: lithium chloride / dimethyl sulfoxide; water / 3 h / 165 °C

3.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 16 h / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 1.5 h / -20 °C

4.2: 16 h / -20 - 20 °C

5.1: palladium diacetate; 1,4-di(diphenylphosphino)-butane; tert-butylamine; propyl cyanide / water / 16 h / 120 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation

6.2: 5 h / 20 °C / 760.05 Torr

7.1: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With TurboGrignard; propyl cyanide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; tetrabutylammomium bromide; palladium diacetate; sodium hydride; tert-butylamine; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; trifluoroacetic acid; lithium chloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; dimethyl sulfoxide; toluene; 2.1: |Krapcho Dealkoxycarbonylation / 5.1: |Suzuki Coupling / 6.1: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.05.082