2-Fluoro-4-iodopyridine-3-carbaldehyde

Base Information

• Chemical Name: 2-Fluoro-4-iodopyridine-3-carbaldehyde
• CAS No.: 153034-82-3
• Molecular Formula: C6H3FINO
• Molecular Weight: 250.999
• Hs Code.: 2933399090
• European Community (EC) Number: 675-076-7
• DSSTox Substance ID: DTXSID70433841
• Nikkaji Number: J566.226E
• Wikidata: Q72473718
• Mol file: 153034-82-3.mol

Synonyms:153034-82-3;2-fluoro-4-iodonicotinaldehyde;4-Iodo-2-fluoro-3-formylpyridine;2-fluoro-4-iodopyridine-3-carbaldehyde;2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;2-FLUORO-3-FORMYL-4-IODOPYRIDINE;2-Fluoro-4-iodo-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 2-fluoro-4-iodo-;MFCD03095290;2-fluoro-4-iodo-pyridine-3-carbaldehyde;2-fluoro-4-iodo-3-pyridinecarbaldehyde;C6H3FINO;SCHEMBL199582;DTXSID70433841;VONGIOGTLFSXDE-UHFFFAOYSA-N;BCP22311;2-Fluoro-3-formyl-4-iodopyridine?;2-fluoro4-iodo-3-pyridinecarbaldehyde;AKOS005258927;CS-W019830;NF-0731;AC-25734;SY007224;pyridine-2-fluoro-4-iodo-3-carboxaldehyde;AM20070236;FT-0649358;EN300-140584;W-205738

Chemical Property of 2-Fluoro-4-iodopyridine-3-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.65
• Boiling Point: 304.229 °C at 760 mmHg
• PKA: -3.62±0.18(Predicted)
• Flash Point: 137.793 °C
• PSA: 29.96000
• Density: 2.081 g/cm³
• LogP: 1.63780
• Storage Temp.: Room temperature.
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 250.92434
• Heavy Atom Count: 10
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-iodonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1I)C=O)F

Technology Process of 2-Fluoro-4-iodopyridine-3-carbaldehyde

There total 5 articles about 2-Fluoro-4-iodopyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-fluoro-3-iodopyridine (113975-22-7) + formic acid ethyl ester (109-94-4) → [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde (153034-82-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; 1.) -75 deg C, 1 h, 2.) -75 deg C, 2 h;

DOI:10.1021/jo00079a031

Reference yield:

2-fluoropyridine (372-48-5) + formic acid ethyl ester (109-94-4) → [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde (153034-82-3)

Guidance literature:

2-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.666667h;

With iodine; In tetrahydrofuran; at -70 ℃; for 1.5h;

formic acid ethyl ester; In tetrahydrofuran; at -70 ℃; for 2h; Inert atmosphere;

Reference yield:

2-fluoro-4-iodopyridine (22282-70-8) + formic acid ethyl ester (109-94-4) → [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde (153034-82-3)

Guidance literature:

2-fluoro-4-iodopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1h;

formic acid ethyl ester; In tetrahydrofuran; at -50 ℃; for 1h;

upstream raw materials:

2-fluoro-3-iodopyridine

formic acid ethyl ester

2-fluoro-4-iodo-3-pyridyllithium

2-fluoropyridine

Downstream raw materials:

1-(3-sulfamoylphenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid

1-(4-fluorophenyl)-4-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)-1,7-naphthyridine

4-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)isoquinoline