5-p-Tolyl-penta-2,4-diynoyl chloride

Base Information

• Chemical Name: 5-p-Tolyl-penta-2,4-diynoyl chloride
• CAS No.: 131292-19-8
• Molecular Formula: C₁₂H₇ClO
• Molecular Weight: 202.64
• Mol file: 131292-19-8.mol

Synonyms:

Chemical Property of 5-p-Tolyl-penta-2,4-diynoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-p-Tolyl-penta-2,4-diynoyl chloride

There total 6 articles about 5-p-Tolyl-penta-2,4-diynoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-methylphenyl)prop-2-ynoic acid (2227-58-9) → 5-p-Tolyl-penta-2,4-diynoyl chloride (131292-19-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

2: 91 percent / Et₃N / toluene / 3 h / Ambient temperature

3: 68 percent Spectr_. / 1 h / 500 °C / 0 - 0.1 Torr

4: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

5: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In diethyl ether; water; toluene;

DOI:10.1039/P19940002461

Reference yield:

p-Tolyl-propynoyl chloride (62849-00-7) → 5-p-Tolyl-penta-2,4-diynoyl chloride (131292-19-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / Et₃N / toluene / 3 h / Ambient temperature

2: 68 percent Spectr_. / 1 h / 500 °C / 0 - 0.1 Torr

3: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

4: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In diethyl ether; water; toluene;

DOI:10.1039/P19940002461

Reference yield:

ethyl 3-(4-methylphenyl)prop-2-ynoate (52188-06-4) → 5-p-Tolyl-penta-2,4-diynoyl chloride (131292-19-8)

Guidance literature:

Multi-step reaction with 6 steps

1: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

2: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

3: 91 percent / Et₃N / toluene / 3 h / Ambient temperature

4: 68 percent Spectr_. / 1 h / 500 °C / 0 - 0.1 Torr

5: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

6: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In diethyl ether; water; toluene;

DOI:10.1039/P19940002461

upstream raw materials:

5-p-Tolyl-pentadiin-(2.4)-saeure

3-(4-methylphenyl)prop-2-ynoic acid

p-Tolyl-propynoyl chloride

ethyl 3-(4-methylphenyl)prop-2-ynoate

Downstream raw materials:

ethyl 7-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenehepta-4,6-diynoate