2227-58-9

Basic information

• Product Name: 3-(4-methylphenyl)prop-2-ynoic acid
• Synonyms: 2-propynoic acid, 3-(4-methylphenyl)-
• CAS NO: 2227-58-9
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.1693
• Mol File: 2227-58-9.mol
• Article Data: 90

Chemical Properties

• Boiling Point: 311.4°C at 760 mmHg
• Flash Point: 156.4°C
• Density: 1.2g/cm³
• Vapor Pressure: 0.000242mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 3-(4-methylphenyl)prop-2-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)prop-2-ynoic acid(2227-58-9)
• EPA Substance Registry System: 3-(4-methylphenyl)prop-2-ynoic acid(2227-58-9)

Safety Data

• Hazardous Substances Data: 2227-58-9(Hazardous Substances Data)

Usage

Description

3-(4-methylphenyl)prop-2-ynoic acid, also known as 4'-methyl-2-phenylpropiolic acid, is a chemical compound characterized by the molecular formula C10H8O2. It is a carboxylic acid featuring a terminal alkyne group and a phenyl ring with a methyl substituent. This unique structure and reactivity make it a versatile compound in various scientific and industrial applications.

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-(4-methylphenyl)prop-2-ynoic acid is utilized as a starting material in organic synthesis for the preparation of a range of pharmaceuticals and agrochemicals. Its chemical properties allow for the creation of diverse compounds with potential therapeutic and pesticidal effects.
Used in Materials Science:
In the field of materials science, 3-(4-methylphenyl)prop-2-ynoic acid is employed for its potential to contribute to the development of new materials. Its structural features make it a candidate for enhancing material properties or creating novel materials with specific characteristics.
Used in Nanotechnology:
3-(4-methylphenyl)prop-2-ynoic acid also finds applications in nanotechnology, where its unique structure and reactivity can be leveraged to synthesize nanoscale materials with distinct electronic, optical, or catalytic properties.
Used in Biological Research:
3-(4-methylphenyl)prop-2-ynoic acid has been studied for its potential biological activities, such as anti-inflammatory and anticancer properties. It is used as a subject of research to explore its effects on biological systems and its potential as a therapeutic agent.
Each of these applications takes advantage of the compound's distinctive chemical structure, which allows for a wide range of reactions and interactions in various fields.

Upstream product

• 766-97-2 4-n-methylphenylacetylene 
• 124-38-9 carbon dioxide 
• 2200-91-1 4-ethynylphenol 
• 16017-24-6 3-p-tolylprop-2-yn-1-ol 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 148547-94-8 methyl 2,3-dibromo-3-p-tolylpropionic acid methyl ester 
• 7560-43-2 methyl 3-(4-methylphenyl)acrylate 
• 1866-39-3 4-methylcinnamic acid 
• 52916-86-6 2,3-dibromo-3-p-tolyl-propionic acid 
• 7515-16-4 methyl 3-(4-methylphenyl)prop-2-ynoate 
• 4186-14-5 1-(2-(trimethylsilyl)ethynyl)toluene 
• 104-87-0 4-methyl-benzaldehyde 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 

Downstream Products

• 7515-16-4 methyl 3-(4-methylphenyl)prop-2-ynoate 
• 52188-06-4 ethyl 3-(4-methylphenyl)prop-2-ynoate 
• 32050-01-4 1-(4-methylphenyl)-7-methyl-2,3-naphthalenedicarboxylic anhydride 
• 151589-34-3 3-(4-methylphenyl)-2-propynenitrile 
• 766-97-2 4-n-methylphenylacetylene 
• 2749-93-1 1-methyl-4-(1-propyn-1-yl)benzene 
• 77930-53-1 7,10-Dimethyl-8-p-tolyl-fluoranthene 
• 77930-62-2 7,10-Dimethyl-9-p-tolyl-fluoranthene-8-carboxylic acid 
• 77930-54-2 7,10-Diethyl-8-p-tolyl-fluoranthene 
• 77930-63-3 7,10-Diethyl-9-p-tolyl-fluoranthene-8-carboxylic acid 
• 77930-55-3 7,10-Dipropyl-8-p-tolyl-fluoranthene 
• 77945-43-8 7,10-Dipropyl-9-p-tolyl-fluoranthene-8-carboxylic acid 
• 77930-56-4 7,10-Dibutyl-8-p-tolyl-fluoranthene 
• 77930-64-4 7,10-Dibutyl-9-p-tolyl-fluoranthene-8-carboxylic acid 

Relevant articles and documents

Porous Carbon Nitride Frameworks Derived from Covalent Triazine Framework Anchored Ag Nanoparticles for Catalytic CO2 Conversion

Porous carbon nitride frameworks (PCNFs) with uniform and rich nitrogen dopants and abundant porosity were successfully fabricated through the direct carbonization of the covalent triazine frameworks (CTFs) at different pyrolysis temperatures and used as supports to anchor and stabilize Ag nanoparticles (NPs) for catalytic CO2 conversion. Importantly, the pyrolysis temperature plays a crucial role in the properties of porous carbon nitride frameworks. The material carbonized at 700 °C showed the highest surface area and micro- and mesoporous structure with a certain interlayer distance. Taking advantage of their unique surface characteristics, PCNF-supported Ag NP catalysts (Ag/PCNF-T, T=pyrolysis temperature) were prepared by a simple chemical method. A series of characterizations revealed that Ag NPs are embedded in the porous carbon nitride frameworks and confined to a relatively small size with high dispersion owing to the assistance of the abundant surface groups and porous structures. The as-obtained Ag/PCNF-T catalysts, especially Ag/PCNF-700, showed excellent catalytic activity, selectivity, and stability for the carboxylation of CO2 with terminal alkynes under mild conditions. This can be due to the existence of abundant nitrogen atoms and diverse porosity, which resulted in highly efficient catalytic activity and stability.

Enantioselective hydroesterificative cyclization of 1,6-enynes to chiral γ-lactams bearing a quaternary carbon stereocenter

A palladium-catalyzed asymmetric hydroesterification-cyclization of 1,6-enynes with CO and alcohol was developed to efficiently prepare a variety of enantioenriched γ-lactams bearing a chiral quaternary carbon center and a carboxylic ester group. The approach featured good to high chemo-, region-, and enantioselectivities, high atom economy, and mild reaction conditions as well as broad substrate scope. The correlation between the multiple selectivities of such process and the N-substitutes of the amide linker in the 1,6-enyne substrate has been depicted by the crystallographic evidence and control experiments.

Pre-carbonized nitrogen-rich polytriazines for the controlled growth of silver nanoparticles: Catalysts for enhanced CO2chemical conversion at atmospheric pressure

High catalytic activity and sufficient durability are two unavoidable key indices of an efficient heterogeneous catalyst for the direct carboxylation of terminal alkynes with CO2 conversion. Nitrogen-rich covalent triazine frameworks (CTFs) are promising substrates, while random distribution of some residual -NH2 groups brings challenges to the controlled growth of catalytic species. Here, we adopt a pre-carbonization protocol, annealing below the carbonization temperature, to eliminate the random -NH2 groups in CTFs and meanwhile to promote polycondensation degree under the premise of maintaining the pore structure. Benefiting from the improved condensation and orderly N atoms, p-CTF-250, for which CTFs are annealed at 250 °C, exhibits improved CO2 adsorption capacity and the ability to control the growth of Ag NPs. Mono-dispersed Ag NPs are generated controllably and entrapped to form Ag@p-CTF-250 catalysts. These Ag@p-CTF-250 catalysts were employed in the direct carboxylation of various terminal alkynes with CO2 under mild conditions (50 °C, 1 atm) and showed excellent catalytic activity. In addition, these catalysts have robust recyclability and can be used for at least 5 catalytic runs while retaining yield above 90%. CO2 conversion proceeds well under the synergistic effect between the high CO2 capture capability and the uniform tiny Ag NPs in Ag@p-CTF-250 "nanoreactors". The results represent an efficient strategy for controlling the growth of metallic nanoparticles in porous organic polymer substrates containing disordered heteroatoms.