Chemical Property of (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
Chemical Property:
- Boiling Point:604.093 °C at 760 mmHg
- PKA:13.76±0.40(Predicted)
- Flash Point:319.144 °C
- PSA：61.02000
- Density:1.281 g/cm3
- LogP:3.04540
- Storage Temp.:-20°C
- Solubility.:Soluble in DMSO (>25 mg/ml)
- XLogP3:2.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:332.16371127
- Heavy Atom Count:25
- Complexity:480
- Purity/Quality:
-
99%, *data from raw suppliers
(E)-(4-(2-(1H-Indazol-3-yl)vinyl)-phenyl)(piperazin-1-yl)methanone 97% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43
- Isomeric SMILES:C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43
- Recent ClinicalTrials:An Ascending Dose Study of KW-2449 in Acute Leukemias, Myelodysplastic Syndromes, and Chronic Myelogenous Leukemia
-
Description
KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3
