BAY 869766

Base Information

• Chemical Name: BAY 869766
• CAS No.: 923032-38-6
• Molecular Formula: C₁₉H₂₀F₃IN₂O₅S
• Molecular Weight: 572.344
• Hs Code.: 2933998090

Synonyms:Refametinib (R enantiomer);Refametinib;Refametinib R enantiomer;

Chemical Property of BAY 869766

Chemical Property:

• Boiling Point: 566.9±60.0 °C (760 mmHg)
• PSA: 116.27000
• Density: 1.82±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 4.70510

Purity/Quality:

97% ^*data from raw suppliers

RefametinibRenantiomer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BAY 869766

There total 27 articles about BAY 869766 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide (1262760-18-8) → Refametinib (923032-37-5,923032-38-6)

Guidance literature:

With pyridine; sulfolane; hydrogenchloride; In water; for 1.5h;

Reference yield: 91.6%

3,4-difluoro-N2-(2-fluoro-4-iodo-phenyl)-6-methoxy-benzene-1,2-diamine (923032-74-0) + (S)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonyl chloride (1262760-00-8) → Refametinib (923032-37-5,923032-38-6)

Guidance literature:

With pyridine; sulfolane; tetrabutylammomium bromide; at 70 ℃; for 18h;

Reference yield: 90.5%

3,4-difluoro-N2-(2-fluoro-4-iodo-phenyl)-6-methoxy-benzene-1,2-diamine (923032-74-0) + 1-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}cyclopropanesulfonyl bromide (1415503-37-5) → (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (923032-37-5,923032-38-6)

Guidance literature:

With pyridine; sulfolane; at 23 ℃; for 18h;

upstream raw materials:

1-allyl-N-(3.4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)cyclopropane-1-sulfonamide

N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

(S)-5-((1-iodocyclopropyl)methyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

(S)-3-(1-iodocyclopropyl)propane-1,2-diol

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