4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid

Base Information

• Chemical Name: 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid
• CAS No.: 935253-43-3
• Molecular Formula: C₃₇H₃₇ClN₄O₃
• Molecular Weight: 621.179
• Mol file: 935253-43-3.mol

Synonyms:

Chemical Property of 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid

There total 16 articles about 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate (935253-23-9) → 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid (935253-43-3,935253-44-4,935253-45-5)

Guidance literature:

methyl 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃;

With hydrogenchloride; In water; pH=2;

Reference yield:

1-(2-bromoethyl)-4-hydroxymethylbenzene → 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid (935253-43-3,935253-44-4,935253-45-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: formic acid; hydroxylamine hydrochloride / 2 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

5.1: borane-THF / tetrahydrofuran / -15 °C

6.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

7.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

8.1: potassium carbonate / acetonitrile / 12 h / Reflux

9.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 80 °C

10.1: water; lithium hydroxide / tetrahydrofuran / 60 °C

10.2: pH 2

With n-butyllithium; formic acid; borane-THF; trimethylsilylazide; hydroxylamine hydrochloride; water; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; lithium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

4-(2-bromoethyl)benzonitrile (72054-56-9) → 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid (935253-43-3,935253-44-4,935253-45-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

3.1: borane-THF / tetrahydrofuran / -15 °C

4.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / 12 h / Reflux

7.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 80 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 60 °C

8.2: pH 2

With n-butyllithium; formic acid; borane-THF; trimethylsilylazide; water; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; lithium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

methyl 4-((3E)-4-{2-[(4-tert-butyl-2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

4-(2-bromoethyl)benzonitrile

2-chloro-4-(tert-butyl)benzyl bromide

methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate