CT 51464

Base Information

• Chemical Name: CT 51464
• CAS No.: 685544-95-0
• Molecular Formula: C₂₁H₂₉N₅O₅
• Molecular Weight: 431.492
• Mol file: 685544-95-0.mol

Synonyms:

Chemical Property of CT 51464

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CT 51464

There total 11 articles about CT 51464 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester (685544-36-9) → 3-({2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl}amino)propionic acid ethyl ester (685544-95-0)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In ethanol; at 20 ℃;

DOI:10.1021/jm030354b

Reference yield:

8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione (34702-66-4) → 3-({2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl}amino)propionic acid ethyl ester (685544-95-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Et₃N / dimethylformamide / 20 °C

2.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

3.1: NaBH₄ / methanol / 0 - 20 °C

3.2: NaBH₄; TFA / 0 - 20 °C

3.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

4.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

5.1: 92 percent / Et₃N / CH₂Cl₂ / 9 h / 20 °C

6.1: hydroxylamine hydrochloride; Et₃N / ethanol / 20 °C

With sodium tetrahydroborate; 10% Cd/Pd; hydroxylamine hydrochloride; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm030354b

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 3-({2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl}amino)propionic acid ethyl ester (685544-95-0)

Guidance literature:

Multi-step reaction with 10 steps

1.1: Et₃N; molecular sieves 4A / CH₂Cl₂ / 20 °C

2.1: 55.10 g / ethanol; H₂O / 2 h / Heating

3.1: 98 percent / aq. HCl / 72 h / Heating

4.1: DCC / dimethylformamide / 2 h / 20 °C

5.1: Et₃N / dimethylformamide / 20 °C

6.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

7.1: NaBH₄ / methanol / 0 - 20 °C

7.2: NaBH₄; TFA / 0 - 20 °C

7.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

8.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

9.1: 92 percent / Et₃N / CH₂Cl₂ / 9 h / 20 °C

10.1: hydroxylamine hydrochloride; Et₃N / ethanol / 20 °C

With hydrogenchloride; sodium tetrahydroborate; 10% Cd/Pd; 4 A molecular sieve; hydroxylamine hydrochloride; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Knoevenagel condensation;

DOI:10.1021/jm030354b

upstream raw materials:

3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

1-phenylmethyl-4-piperidone

ethyl 3-isocyanatopropanoate

Refernces