3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

Base Information

Chemical Name:3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester
CAS No.:685544-36-9
Molecular Formula:C₂₁H₂₆N₄O₄
Molecular Weight:398.462
Hs Code.:

Synonyms:3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

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Chemical Property of 3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

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Technology Process of 3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

There total 9 articles about 3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5100-34-5
ethyl 3-isocyanatopropanoate

: 685544-34-7
4-(1-oxo-2,8-diazaspiro[4.5]dec-2-yl)benzonitrile

: 685544-36-9
3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 9h;
DOI:10.1021/jm030354b

Reference yield:

: 34702-66-4
8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

: 685544-36-9
3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / dimethylformamide / 20 °C

2.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

3.1: NaBH₄ / methanol / 0 - 20 °C

3.2: NaBH₄; TFA / 0 - 20 °C

3.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

4.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

5.1: 92 percent / Et₃N / CH₂Cl₂ / 9 h / 20 °C

With sodium tetrahydroborate; 10% Cd/Pd; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030354b

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 685544-36-9
3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: Et₃N; molecular sieves 4A / CH₂Cl₂ / 20 °C

2.1: 55.10 g / ethanol; H₂O / 2 h / Heating

3.1: 98 percent / aq. HCl / 72 h / Heating

4.1: DCC / dimethylformamide / 2 h / 20 °C

5.1: Et₃N / dimethylformamide / 20 °C

6.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

7.1: NaBH₄ / methanol / 0 - 20 °C

7.2: NaBH₄; TFA / 0 - 20 °C

7.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

8.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

9.1: 92 percent / Et₃N / CH₂Cl₂ / 9 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; 10% Cd/Pd; 4 A molecular sieve; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Knoevenagel condensation;
DOI:10.1021/jm030354b