1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-5-nitro-

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-5-nitro-
CAS No.:858340-88-2
Molecular Formula:C₁₂H₁₂N₄O₂
Molecular Weight:244.253
Hs Code.:

Synonyms:Benzene,1-(1,1-dimethylethyl)-5-methyl-2,4-dinitro;1-tert-butyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;

Suppliers and Price of 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-5-nitro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-5-nitro-

Chemical Property:

PSA：87.43000
LogP:3.09438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-5-nitro-

There total 2 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-dimethylethyl)-5-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: C₁₄H₁₄N₂O

: 34461-00-2
nitromalondialdehyde sodium salt

: 858340-88-2
1-tert-butyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.11.026

Reference yield: 81.5%

: 269726-49-0
2-amino-1-tert-butyl-4-cyanopyrrole

: 34461-00-2
nitromalondialdehyde sodium salt

: 858340-88-2
1-tert-butyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: 2-amino-1-tert-butyl-4-cyanopyrrole; nitromalondialdehyde sodium salt; In propan-1-ol; at 20 ℃;

With hydrogenchloride; In propan-1-ol; water; at 4 - 100 ℃; for 20h;

Reference yield: 44.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 858340-88-2
1-tert-butyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

: C₁₇H₁₅N₅O₂

: C₁₇H₁₅N₅O₂

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 130 ℃; for 16h; regioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/cctc.201402715