269726-49-0

Usage

Uses

Used in Chemical Synthesis:
5-Amino-1-(tert-butyl)-1H-pyrrole-3-carbonitrile is used as a synthetic intermediate for the preparation of various organic compounds and pharmaceuticals. Its unique structure and functional groups make it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 5-Amino-1-(tert-butyl)-1H-pyrrole-3-carbonitrile is used as a potential lead compound for the development of new drugs. Its heterocyclic structure and functional groups may contribute to the discovery of novel therapeutic agents with unique mechanisms of action.
Used in Material Science:
5-Amino-1-(tert-butyl)-1H-pyrrole-3-carbonitrile may be utilized in the development of new materials with specific properties, such as conductivity, stability, or reactivity. Its incorporation into polymers or other materials could lead to innovative applications in various industries.
Used in Agrochemicals:
5-Amino-1-(tert-butyl)-1H-pyrrole-3-carbonitrile could be employed as a starting material or intermediate in the synthesis of agrochemicals, such as pesticides or herbicides. Its unique structure may contribute to the development of more effective and environmentally friendly products.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 5-Amino-1-(tert-butyl)-1H-pyrrole-3-carbonitrile may be used as a precursor for the synthesis of novel dyes and pigments with improved color properties, stability, and application versatility. Its heterocyclic structure and functional groups could lead to the creation of new colorants with unique characteristics.

InChI:InChI=1/C9H13N3/c1-9(2,3)12-6-7(5-10)4-8(12)11/h4,6H,11H2,1-3H3

Upstream product

• 75-64-9 tert-butylamine 
• 269726-48-9 N-tert-butylaminomethylenesuccinonitrile 
• 89283-73-8 (E,Z)-2-formylsuccinonitrile potassium salt 
• 110-61-2 butanedinitrile 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 915726-39-5 6-amino-1-tert-butyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1146221-74-0 1-tert-butyl-6-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1146221-73-9 1-tert-butyl-4,6-bis(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1146221-75-1 1-tert-butyl-6-phenyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1146221-77-3 1-tert-butyl-4-[chloro(difluoro)methyl]-6-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1260673-54-8 C₂₁H₁₉N₃O₄ 
• 4414-89-5 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1273122-75-0 C₁₇H₁₄N₂O₃ 
• 1273122-77-2 C₁₇H₁₃FN₂O₃ 
• 1273122-79-4 C₁₇H₁₃FN₂O₃ 
• 1273122-81-8 C₁₇H₁₃ClN₂O₃ 
• 1273122-83-0 C₁₈H₁₆N₂O₃ 
• 1273122-85-2 C₁₈H₁₆N₂O₄ 
• 1273122-87-4 C₁₉H₁₈N₂O₅ 

Relevant academic research and scientific papers

NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB

The present invention relates to novel processes for the manufacture of N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (I), wherein no protection-deprotection sequences or halogenation steps are required and the use of palladium catalysts is minimized. Formula (I)

PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES

Disclosed are materials and methods for preparing substituted 4,5-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-3(1H)-ones of formula (1), Compounds of formula (1) inhibit one or more members of the Janus Kinase (JAK) family of cytoplasmic protein tyrosine kinases, and are useful for treating disorders, diseases, and conditions associated with the immune system, inflammation, and abnormal cell growth.

Acrosin structure-based design, synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors

A series of 7-azaindol derivatives were designed based on the homologous 3D model of human acrosin. These compounds were synthesized and evaluated for their human acrosin inhibitory activities in vitro. Compounds 7a, 7i, 7j, 7k and 7n showed highly inhibitory activity against human acrosin. The three-dimensional structure-activity relationship was investigated through a CoMFA model, which provided valuable information to further study of potential human acrosin inhibitors.

METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA

This invention relates to methods for treating, managing and preventing cognitive impairment associated with various diseases and disorders, age-associated memory impairment, and dementia.

A practical synthesis of 7-azaindolylcarboxy-endo-tropanamide (DF 1012)

An optimised cost-effective synthesis of the new antitussive drug, DF1012, is herewith reported. The new synthetic route to the key intermediate DF1005 is based on the unusual deprotection step of the 1-tert-butyl-3-cyano-7-azaindole intermediate, which can also be regarded as a convenient way for the industrial production of the expensive 7-azaindole 1. The second key intermediate, endo-tropanamine 6, was obtained in high yield by a novel one-pot stereoselective process using a Pd-catalysed reductive amination procedure.