Chemical Property of N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
Chemical Property:
- Vapor Pressure:0.000141mmHg at 25°C
- Refractive Index:1.543
- Boiling Point:323.1 °C at 760 mmHg
- PKA:7.61±0.43(Predicted)
- Flash Point:149.2 °C
- PSA：49.33000
- Density:1.561 g/cm3
- LogP:5.40850
- Storage Temp.:−20°C
- Sensitive.:Light Sensitive
- Solubility.:Solubility: DMSO (5 mg/ml) or Ethanol (1 mg/ml).
- XLogP3:6.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:2
- Exact Mass:383.0147752
- Heavy Atom Count:25
- Complexity:462
- Purity/Quality:
-
99%, *data from raw suppliers
IMD0354 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
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Uses
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes. IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
