Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Base Information

Chemical Name:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester
CAS No.:133463-05-5
Molecular Formula:C₄₄H₄₄N₅O₁₁P
Molecular Weight:849.834
Hs Code.:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

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Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

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Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

There total 4 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68892-40-0
N⁴-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine

: 133463-05-5
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrazole / CH₂Cl₂ / 0.75 h

2: mCPBA / CH₂Cl₂ / 0.33 h

3: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

4: mesitylenedisulfonyl chloride / acetonitrile / 2 h

With 1H-tetrazole; chloro-trimethyl-silane; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

: 133462-96-1
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

: 133463-05-5
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

2: mesitylenedisulfonyl chloride / acetonitrile / 2 h

With chloro-trimethyl-silane; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; triethylamine; In acetonitrile;
DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

: Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

: 133463-05-5
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: mCPBA / CH₂Cl₂ / 0.33 h

2: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

3: mesitylenedisulfonyl chloride / acetonitrile / 2 h

With chloro-trimethyl-silane; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)92637-6