Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

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Chemical Name:Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester
CAS No.:133462-99-4
Molecular Formula:C₃₈H₃₈N₃O₁₁P
Molecular Weight:743.707
Hs Code.:

Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

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Chemical Property of Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

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Technology Process of Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

There total 3 articles about Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133462-96-1
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

: 133462-99-4
Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

Guidance literature:: With chloro-trimethyl-silane; triethylamine; In acetonitrile; at 75 ℃; for 1h; Yield given;
DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

: 68892-40-0
N⁴-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine

: 133462-99-4
Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrazole / CH₂Cl₂ / 0.75 h

2: mCPBA / CH₂Cl₂ / 0.33 h

3: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

With 1H-tetrazole; chloro-trimethyl-silane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

: Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

: 133462-99-4
Phosphoric acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: mCPBA / CH₂Cl₂ / 0.33 h

2: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

With chloro-trimethyl-silane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)92637-6