3-Fluorobenzyl cyanide

Base Information

• Chemical Name: 3-Fluorobenzyl cyanide
• CAS No.: 10036-43-8
• Molecular Formula: C8H6FN
• Molecular Weight: 135.141
• Hs Code.: 2926909090
• Mol file: 10036-43-8.mol

Synonyms:3-Fluorophenylacetonitrile;

Chemical Property of 3-Fluorobenzyl cyanide

Chemical Property:

• Vapor Pressure: 0.0802mmHg at 25°C
• Refractive Index: 1.507
• Boiling Point: 226.8 °C at 760 mmHg
• Flash Point: 83.1 °C
• PSA: 23.79000
• Density: 1.127 g/cm³
• LogP: 1.89178

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-2-phenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:; R36/37/38:
• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:; R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluorobenzyl cyanide

There total 14 articles about 3-Fluorobenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

phenylacetonitrile (140-29-4) → α-(Fluorophenyl)acetonitrile (10036-43-8)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In 1,2-dimethoxyethane; at 25 ℃; electrochemical reaction: Pt wire as working electrode, Pt foil counter electrode and Pd/H₂ reference electrode;

DOI:10.1016/S0022-1139(98)00267-X

Reference yield: 65.0%

(RS)-mandelonitrile (532-28-5,613-88-7) → α-(Fluorophenyl)acetonitrile (10036-43-8)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmc.2011.07.062

Reference yield: 22.0%

phenylacetonitrile (140-29-4) → 2-acetamido-2-phenylacetonitrile (39149-34-3) + α-(Fluorophenyl)acetonitrile (10036-43-8)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; triethylamine tris(hydrogen fluoride); In acetonitrile; at 13 ℃; anodic oxidation;

DOI:10.1016/S0040-4020(01)89079-7

upstream raw materials:

bromostyrene

phenyl(trimethylsiloxy)acetonitrile

phenylacetonitrile

2-fluoro-2-phenylacetamide

Downstream raw materials:

phenyl-2 fluoro-2 amino-1 ethane chlorhydrate

Refernces

• 1、 Sawamura, Takahiro,Kuribayashi, Shunsuke,Lnagi, Shinsuke,Fuchigami, Toshio. "Use of Task-Specific Ionic liquid for selective electrocatalytic fluorination". . p. 644 - 646. Retrieved 2010.
• 2、 Turkman, Nashaat,Shavrin, Aleksander,Ivanov, Roman A.,Rabinovich, Brian,Volgin, Andrei,Gelovani, Juri G.,Alauddin, Mian M.. "Fluorinated cannabinoid CB2 receptor ligands: Synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives". experimental part. p. 5698 - 5707. Retrieved 2011/10/13.