ALPHA-(TRIMETHYLSILYLOXY)PHENYLACETONIT&

Base Information

• Chemical Name: ALPHA-(TRIMETHYLSILYLOXY)PHENYLACETONIT&
• CAS No.: 25438-37-3
• Molecular Formula: C9H15NOSi
• Molecular Weight: 205.332
• Hs Code.: 2931900090
• Mol file: 25438-37-3.mol

Synonyms:ALPHA-(TRIMETHYLSILYLOXY)PHENYLACETONIT&;α-(trimethylsilyloxy)phenylacetonitrile;(Trimethylsiloxy)phenylacetonitrile;2-(Trimethylsilyloxy)-2-phenylethanenitrile;Phenyl(trimethylsiloxy)acetonitrile;Phenyl(trimethylsilyloxy)acetonitrile;α-[(Trimethylsilyl)oxy]benzeneacetonitrile;

Chemical Property of ALPHA-(TRIMETHYLSILYLOXY)PHENYLACETONIT&

Chemical Property:

• Vapor Pressure: 0.021mmHg at 25°C
• Refractive Index: 0.978
• Boiling Point: 251 °C at 760 mmHg
• Flash Point: 105.6 °C
• PSA: 33.02000
• Density: 0.987 g/cm³
• LogP: 3.10278
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Benzene (Slightly), Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Phenyl-2-[(trimethylsilyl)oxy]acetonitrile(90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 23-27-36/37/39-45-7/9

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ALPHA-(TRIMETHYLSILYLOXY)PHENYLACETONIT&

There total 24 articles about ALPHA-(TRIMETHYLSILYLOXY)PHENYLACETONIT& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trimethylsilyl cyanide (7677-24-9) + benzaldehyde (100-52-7) → phenyl(trimethylsiloxy)acetonitrile (25438-37-3)

Guidance literature:

tris(bis(trimethylsilyl)amido)samarium(III); In tetrahydrofuran; at 0 ℃; for 4h;

DOI:10.1021/jo00088a068

Reference yield: 95.0%

chloro-trimethyl-silane (75-77-4) + potassium cyanide (151-50-8) + benzaldehyde (100-52-7) → phenyl(trimethylsiloxy)acetonitrile (25438-37-3)

Guidance literature:

With Amberlite XAD-2 resin; In acetonitrile; at 60 ℃; for 8h;

DOI:10.1246/bcsj.60.3820

Reference yield: 94.0%

chloro-trimethyl-silane (75-77-4) + lithium cyanide (2408-36-8) + benzaldehyde (100-52-7) → phenyl(trimethylsiloxy)acetonitrile (25438-37-3)

Guidance literature:

In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1055/s-1986-31873

upstream raw materials:

trimethylsilyl cyanide

benzaldehyde

chloro-trimethyl-silane

(RS)-mandelonitrile

Downstream raw materials:

4-chloro-1-phenylbutan-1-one

1-phenylbut-3-en-1-one

3-Oxo-3-phenylpropanal 1-(diethylacetal)

2-phenyl-2-trimethylsilyloxypropanenitrile

Refernces

• 1、 Lin, Xiao-Ming,Niu, Ji-Liang,Wen, Pei-Xian,Lu, Yan-Na,Hu, Lei,Zhang, Da-Liang,Cai, Yue-Peng. "From 1D to 3D lanthanide coordination polymers constructed with pyridine-3,5-dicarboxylic acid: Synthesis, crystal structures, and catalytic properties". . p. 63425 - 63432. Retrieved 2016.
• 2、 Moreno, José María,Velty, Alexandra,Díaz, Urbano,Corma, Avelino. "Synthesis of 2D and 3D MOFs with tuneable Lewis acidity from preformed 1D hybrid sub-domains". . p. 2053 - 2066. Retrieved 2019.
• 3、 Fernández De Luis, Roberto,Urtiaga, M. Karmele,Mesa, José L.,Larrea, Edurne S.,Iglesias, Marta,Rojo, Teófilo,Arriortua, María I.. "Thermal response, catalytic activity, and color change of the first hybrid vanadate containing Bpe guest molecules". . p. 2615 - 2626. Retrieved 2013.
• 4、 Pitchaimani, Ponnuchamy,Lo, Kong Mun,Elango, Kuppanagounder P.. "Synthesis, crystal structures, luminescence properties and catalytic application of lanthanide(III) piperidine dithiocarbamate complexes". . p. 8 - 16. Retrieved 2015.
• 5、 Rawat, Varun,Press, Konstantin,Goldberg, Israel,Vigalok, Arkadi. "Straightforward synthesis and catalytic applications of rigid N,O-type calixarene ligands". . p. 11189 - 11193. Retrieved 2015.
• 6、 Dvries, Richard F.,De La Pena-Oshea, Victor A.,Snejko, Natalia,Iglesias, Marta,Gutierrez-Puebla, Enrique,Monge, M. Angeles. "Insight into the correlation between net topology and ligand coordination mode in new lanthanide MOFs heterogeneous catalysts: A theoretical and experimental approach". . p. 5535 - 5545. Retrieved 2012.
• 7、 Hayashi, Yoshihito,Kawabata, Hiroko,Kikukawa, Yuji. "Synthesis of cyanooxovanadate and cyanosilylation of ketones". . p. 31688 - 31692. Retrieved 2021/11/30.
• 8、 Sato, Eisuke,Fujii, Mayu,Tanaka, Hiroki,Mitsudo, Koichi,Kondo, Masaru,Takizawa, Shinobu,Sasai, Hiroaki,Washio, Takeshi,Ishikawa, Kazunori,Suga, Seiji. "Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis". supporting information. p. 16035 - 16044. Retrieved 2021/09/02.