Technology Process of (2S)-cis-1-(phenylsulfonyl)-5-butyl-2-(1-<(phenylsulfonyl)oxy>heptyl)pyrrolidine
There total 7 articles about (2S)-cis-1-(phenylsulfonyl)-5-butyl-2-(1-<(phenylsulfonyl)oxy>heptyl)pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / calcined K2CO3 / acetonitrile / 1.) 0 deg C, 30 min, 2.) RT, 16 h
2: 81 percent / acetic acid, water / propan-1-ol / 6 h / Heating
3: 70 percent / diethyl ether / 1.) - 78 deg C, 1 h, 2.) 0 deg C, 12 h
4: 99 percent / H2 / 10percent Pd/C / acetic acid / 10 h / 2844.3 Torr / Ambient temperature
5: 1.) trimethyloxonium tetrafluoroborate, 2.) N-methylimidazole / 1.) CH2Cl2, RT, 3 h, 2.) RT, 18 h
With
1-methyl-1H-imidazole; calcined K2CO3; water; hydrogen; trimethoxonium tetrafluoroborate; acetic acid;
palladium on activated charcoal;
In
propan-1-ol; diethyl ether; acetic acid; acetonitrile;
DOI:10.1021/jo00208a016
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / H2 / 10percent Pd/C / acetic acid / 10 h / 2844.3 Torr / Ambient temperature
2: 1.) trimethyloxonium tetrafluoroborate, 2.) N-methylimidazole / 1.) CH2Cl2, RT, 3 h, 2.) RT, 18 h
With
1-methyl-1H-imidazole; hydrogen; trimethoxonium tetrafluoroborate;
palladium on activated charcoal;
In
acetic acid;
DOI:10.1021/jo00208a016
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 70 percent / diethyl ether / 1.) - 78 deg C, 1 h, 2.) 0 deg C, 12 h
2: 99 percent / H2 / 10percent Pd/C / acetic acid / 10 h / 2844.3 Torr / Ambient temperature
3: 1.) trimethyloxonium tetrafluoroborate, 2.) N-methylimidazole / 1.) CH2Cl2, RT, 3 h, 2.) RT, 18 h
With
1-methyl-1H-imidazole; hydrogen; trimethoxonium tetrafluoroborate;
palladium on activated charcoal;
In
diethyl ether; acetic acid;
DOI:10.1021/jo00208a016
