((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

Base Information

• Chemical Name: ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)
• CAS No.: 1379822-10-2
• Molecular Formula: C₁₆H₂₀F₂Si₂
• Molecular Weight: 306.503
• Mol file: 1379822-10-2.mol

Synonyms:((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

Chemical Property of ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

There total 1 articles about ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,5-dibromo-2,4-difluorobenzene (28342-75-8) + trimethylsilylacetylene (1066-54-2) → ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) (1379822-10-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 80 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol5010627

Reference yield: 75.0%

((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) (1379822-10-2) → 1,5-diethynyl-2,4-difluorobenzene (1379822-11-3)

Guidance literature:

With methanol; potassium fluoride; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere; Darkness;

DOI:10.1002/chem.201103451

Reference yield:

((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) (1379822-10-2) → 1,5-diethynyl-2,4-bis(p-tolyloxy)benzene (1436919-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 0.17 h

2: potassium tert-butylate / dimethyl sulfoxide / 6 h / 60 °C / Inert atmosphere

With potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1021/jo400668v

upstream raw materials:

1,5-dibromo-2,4-difluorobenzene

trimethylsilylacetylene

Downstream raw materials:

1,5-diethynyl-2,4-difluorobenzene

1,5-diethynyl-2,4-bis(p-tolyloxy)benzene