2-Amino-3-Difluoromethoxy-5-Bromopyridine

Base Information

• Chemical Name: 2-Amino-3-Difluoromethoxy-5-Bromopyridine
• CAS No.: 121936-68-3
• Molecular Formula: C8H7BrO4
• Molecular Weight: 247.045
• Hs Code.: 2918990090
• Mol file: 121936-68-3.mol

Synonyms:2-AMINO-3-DIFLUOROMETHOXY-5-BROMOPYRIDINE;2-Brom-5-fluor-benzamid;2-Brom-5-hydroxy-4-methoxy-benzoesaeure;2-bromo-5-hydroxy-4-methoxy benzoic acid;Benzamide,2-bromo-5-fluoro;

Chemical Property of 2-Amino-3-Difluoromethoxy-5-Bromopyridine

Chemical Property:

• Boiling Point: 367℃
• PKA: 3.00±0.10(Predicted)
• Flash Point: 176℃
• PSA: 48.14000
• Density: 1.757
• LogP: 2.60890

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-hydroxy-4-methoxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-Difluoromethoxy-5-Bromopyridine

There total 8 articles about 2-Amino-3-Difluoromethoxy-5-Bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromoisovanillin (2973-59-3) → 2-bromo-5-hydroxy-4-methoxybenzoic acid (121936-68-3)

Guidance literature:

2-bromoisovanillin; With aminosulfonic acid; In water; ethyl acetate;

With sodium chlorite; In water; ethyl acetate; at -10 - 20 ℃; for 1h;

Reference yield:

2-bromo-5-hydroxy-4-methoxy-benzonitrile (850856-55-2) → 2-bromo-5-hydroxy-4-methoxybenzoic acid (121936-68-3)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/jo01208a017

Reference yield:

isovanillin (621-59-0) → 2-bromo-5-hydroxy-4-methoxybenzoic acid (121936-68-3)

Guidance literature:

Multi-step reaction with 5 steps

3: aqueous alkaline solution

4: acetic acid; sodium acetate; bromine

5: aqueous KOH-solution

With potassium hydroxide; alkaline solution; bromine; sodium acetate; acetic acid;

DOI:10.1021/jo01208a017

upstream raw materials:

2-bromo-4,5-dimethoxybenzoic acid

Isovanillic acid

2-bromo-5-hydroxy-4-methoxy-benzonitrile

isovanillin

Refernces