1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 24334-19-8
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.202
• Hs Code.: 2933990090
• Mol file: 24334-19-8.mol

Synonyms:1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester;

Chemical Property of 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 371.827 °C at 760 mmHg
• Flash Point: 178.675 °C
• PSA: 54.98000
• Density: 1.272 g/cm³
• LogP: 1.73960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl1H-Pyrrolo[2,3-c]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate is a useful research chemical.

Technology Process of 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

There total 10 articles about 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(3-nitropyridin-4-yl)-2-oxopropionic acid ethyl ester (24334-18-7) → ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate (24334-19-8)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 2h; Reflux;

DOI:10.3390/molecules190913342

Reference yield: 59.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 3-amino-4-chloropyridine (20511-15-3) → ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate (24334-19-8)

Guidance literature:

2-oxo-propionic acid ethyl ester; 3-amino-4-chloropyridine; With pyridine; tetraethoxy orthosilicate; pyridinium p-toluenesulfonate; at 20 ℃; for 48h; Inert atmosphere; Darkness;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 160 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield: 18.0%

oxalic acid diethyl ester (95-92-1) + 3-(tert-butyloxycarbonylamino)-4-methyl-pyridine (180253-66-1) → ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate (24334-19-8)

Guidance literature:

3-(tert-butyloxycarbonylamino)-4-methyl-pyridine; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -40 ℃; for 1h; Inert atmosphere;

oxalic acid diethyl ester; In tetrahydrofuran; pentane; at -40 - 20 ℃; for 21.25h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; pentane; for 2h; Heating; Reflux;

upstream raw materials:

2-oxo-propionic acid ethyl ester

3-amino-4-chloropyridine

3-(3-nitropyridin-4-yl)-2-oxopropionic acid ethyl ester

oxalic acid diethyl ester

Downstream raw materials:

1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Ethyl 1-(2-fluoro-4-iodo-benzyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

1-methyl-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

(1H-pyrrolo[2,3-c]pyridin-2-yl)methanamine

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