20511-15-3

Basic information

• Product Name: 3-Amino-4-chloropyridine
• Synonyms: 3-AMINO-4-CHLOROPYRIDINE;3-AMINO-4-CHLORPYRIDINE;4-CHLORO-PYRIDIN-3-YLAMINE;4-CHLORO-3-AMINO PYRIDINE;4-CHLORO-3-PYRIDINAMINE;3-Pyridinamine,4-chloro-(9CI);4-chloropyridin-3-amine;chloropyridin-3-amine
• CAS NO: 20511-15-3
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• EINECS: 1533716-785-6
• Product Categories: PYRIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Series;Amines;Pyridines;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Building Blocks;C5;C5 to C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series
• Mol File: 20511-15-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 59-61°C
• Boiling Point: 247.6 °C at 760 mmHg
• Flash Point: 103.5 °C
• Appearance: White to yellow/Powder or Crystals
• Density: 1.326 g/cm³
• Vapor Pressure: 0.0254mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 0-10°C
• Solubility: soluble in Methanol
• PKA: 3.77±0.10(Predicted)
• BRN: 110187
• CAS DataBase Reference: 3-Amino-4-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-chloropyridine(20511-15-3)
• EPA Substance Registry System: 3-Amino-4-chloropyridine(20511-15-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-41-37/38-25
• Safety Statements: 26-36/37/39-45-39
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 20511-15-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Cryst

InChI:InChI=1/C5H5ClN2/c6-4-1-2-8-3-5(4)7/h1-3H,7H2

Upstream product

• 13091-23-1 4-chloro-3-nitropyridine 
• 39910-67-3 4-azidopyridine 

Downstream Products

• 138769-30-9 N-(4-chloropyridin-3-yl) acetamide 
• 66242-96-4 ethyl 4-chloro-3-pyridinedithiocarbonate 
• 146140-99-0 3-amino-4-phenyl-pyridine 
• 65128-66-7 2-mercapto-pyrido[3,4-d][1,3]thiazole 
• 25797-05-1 3-phenyl-1H-pyrrolo[2,3-c]pyridine 
• 478361-36-3 4-chloro-3-hydrazinylpyridine 
• 1004764-35-5 4-(3-chloropropoxy)-N-(4-chloropyridin-3-yl)benzamide 
• 18504-86-4 2H-pyrido<4,3-b><1,4>thiazin-3(4H)-one 
• 108923-77-9 styryl-2 thiazolo<4,5-c>pyridine 
• 111931-88-5 2-p-Tolyl-selenazolo[4,5-c]pyridine 
• 116608-16-3 2-p-tolylthiazolo<4,5-c>pyridine 
• 89786-57-2 2-methylthiazolo[4,5-c]pyridine 
• 91813-44-4 2-phenylthiazolo<4,5-c>pyridine 
• 62638-73-7 phenyl-thiazolo[4,5-c]pyridin-2-yl-amine 

Relevant articles and documents

Photoswitchable Magnetic Resonance Imaging Contrast by Improved Light-Driven Coordination-Induced Spin State Switch

We present a fully reversible and highly efficient on-off photoswitching of magnetic resonance imaging (MRI) contrast with green (500 nm) and violet-blue (435 nm) light. The contrast change is based on intramolecular light-driven coordination-induced spin state switch (LD-CISSS), performed with azopyridine-substituted Ni-porphyrins. The relaxation time of the solvent protons in 3 mM solutions of the azoporphyrins in DMSO was switched between 3.5 and 1.7 s. The relaxivity of the contrast agent changes by a factor of 6.7. No fatigue or side reaction was observed, even after >100 000 switching cycles in air at room temperature. Electron-donating substituents at the pyridine improve the LD-CISSS in two ways: better photostationary states are achieved, and intramolecular binding is enhanced.

TITANIUM (O) REAGENTS; 4. A SELECTIVE AND EFFICIENT REDUCTION OF NITROPYRIDINE DERIVATIVES

Following the successful applications of a titanium (O) slurry in the deoxygenation of aromatic N-oxides, we attempted to achieve this method for the reduction of a nitro- group in pyridine derivatives.In general, only aminopyridine derivates were formed in 85-98percent yield.The advantage of this excellent reducing agent consists in mild reaction conditions and high yields of products, as well as in the selectivity of the reaction.

Aryl substituted pyrido[1,4]benzodiazepines for treatment of depression

Pyrido[1,4]benzodiazepines having antidepressant activity of the formula STR1 wherein Ar is 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or a substituted phenyl; R is hydrogen, loweralkyl or an amine on the end of a hydrocarbon chain; Z is hydrogen, halogen, trifluoromethyl, loweralkyl, lower-alkoxy, hydroxy or nitro; and Y is hydrogen, loweralkyl, loweralkoxy or hydroxy; and the pharmaceutical salts are prepared from [2-[(aminopyridinyl)amino]phenyl]arylmethanones which also have antidepressant activity.