Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 333743-54-7
• Molecular Formula: C8H18N2O2
• Molecular Weight: 174.243
• Hs Code.: 2924199090
• Mol file: 333743-54-7.mol

Synonyms:Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI);

Chemical Property of Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 264℃
• PKA: 12.51±0.46(Predicted)
• Flash Point: 113℃
• PSA: 64.35000
• Density: 0.984
• LogP: 1.94950
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-N-Boc-Propane-1,2-diamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-propane-1,2-diamine dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3) → tert-butyl (R)-(2-aminopropyl)carbamate (333743-54-7)

Guidance literature:

With sodium hydroxide; In methanol; water; at 5 - 20 ℃; for 19h;

Reference yield: 50.0%

tert-butyl phenyl carbonate (6627-89-0) + (R)-propane-1,2-diamine dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3) → tert-butyl (R)-(2-aminopropyl)carbamate (333743-54-7)

Guidance literature:

(R)-propane-1,2-diamine dihydrochloride; With sodium hydroxide; In ethanol; at 20 ℃; for 2h;

tert-butyl phenyl carbonate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.tet.2014.12.080

Reference yield:

(2R)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]carbamic acid 1,1-dimethylethylester (333743-53-6) → tert-butyl (R)-(2-aminopropyl)carbamate (333743-54-7)

Guidance literature:

With piperidine; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

(2R)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]carbamic acid 1,1-dimethylethylester

tert-butyl phenyl carbonate

(R)-propane-1,2-diamine dihydrochloride

di-tert-butyl dicarbonate

Downstream raw materials:

[(2R)-2-[[2-amino-5-[[(3-chloro-2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]propyl]carbamic acid 1,1-dimethylethyl ester

[(2R)-2-[[2-amino-5-[(phenylmethyl)sulfonyl]thiazolo[4,5-d]pyrimidin-7-yl]amino]propyl]carbamic acid 1,1-dimethylethyl ester

3-[benzyloxycarbonyl-((R)-2-tert-butoxycarbonylamino-1-methyl-ethyl)-amino]-propionic acid methyl ester

(R)-2-(benzyloxycarbonylaminopropyl)carbamic acid tert-butyl ester