37868-26-1

Basic information

• Product Name: 2-Indanylacetic acid
• Synonyms: INDAN-2-YL-ACETIC ACID;2-INDANYLACETIC ACID;2-(2,3-Dihydro-1H-inden-2-yl)acetic acid;2,3-dihydro-1H-inden-1-ylacetic acid;2,3-Dihydro-1H-inden-2-ylacetic acid;Indan-2-ylacetic acid 98%;1H-Indene-2-acetic acid, 2,3-dihydro-;2,3-Dihydro-1H-indene-2-acetic acid
• CAS NO: 37868-26-1
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 37868-26-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 91-93°C
• Boiling Point: 343.28°C at 760 mmHg
• Flash Point: 240.264°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.70±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 2616409
• CAS DataBase Reference: 2-Indanylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Indanylacetic acid(37868-26-1)
• EPA Substance Registry System: 2-Indanylacetic acid(37868-26-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 37868-26-1(Hazardous Substances Data)

Usage

Uses

2-Indanylacetic acid is the starting material in the synthesis of pentacylic core of (+)-Salvileucalin.

Synthesis Reference(s)

The Journal of Organic Chemistry, 26, p. 3555, 1961 DOI: 10.1021/jo01067a631

InChI:InChI=1/C11H12O2/c12-11(13)7-9-6-5-8-3-1-2-4-10(8)9/h1-4,9H,5-7H2,(H,12,13)

Upstream product

• 114915-75-2 1-oxoindan-Δ^2,α-acetic acid 
• 615-13-4 2-indanone 
• 66658-02-4 acetic acid, (1,3-dihydro-2H-inden-2-ylidene)-, methyl ester 
• 53273-37-3 indan-2-yl-acetic acid methyl ester 
• 4471-33-4 3,3a,4,8b-tetrahydroindeno<1,2-b>furan-2-one 
• 157406-12-7 (E)-2-(1-oxo-1,3-dihydro-2H-inden-2-ylidene)acetic acid 
• 83-33-0 inden-1-one 

Downstream Products

• 143356-09-6 ethyl 2-indanylacetate 
• 53273-37-3 indan-2-yl-acetic acid methyl ester 
• 146737-88-4 ethyl-trans-3-[2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]acrylate 
• 146737-89-5 ethyl-3-[2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]propionate 
• 4471-33-4 3,3a,4,8b-tetrahydroindeno<1,2-b>furan-2-one 
• 17496-14-9 2,3-dihydro-2-methyl-1H-inden-1-one 
• 351490-85-2 1,1-dimethyl-2-(indan-2-yl)ethylamine 
• 772-28-1 2-(indan-2-yl)ethanol 
• 38425-66-0 2-(indan-1-yl)ethanol 

Relevant articles and documents

Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation

A new approach has elaborated on the conversion of γ-lactones to the corresponding NH γ-lactams that can serve as γ-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH γ-lactam building blocks starting from γ-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.

Synthesis of the pentacylic core of (+)-salvileucalin B

A concise preparation of the prochiral pentacyclic core of (+)-salvileucalin B is presented. The key feature in the synthesis is the Cu-catalyzed intramolecular cyclopropanation of a symmetrical indane-derived α-diazo β-keto ester. This symmetry is carrie

TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.