4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• CAS No.: 374794-84-0
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.319
• Hs Code.: 2933399990
• Mol file: 374794-84-0.mol

Synonyms:4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 2-Methyl-2-propanyl 4,4-bis(hydroxymethyl)-1-piperidinecarboxylate; tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate; 4,4-Bis(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 364℃
• Flash Point: 174℃
• PSA: 70.00000
• Density: 1.113
• LogP: 0.92620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4,4-bis(hydroxymethyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 10 articles about 4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(tert-butyl) 4,4-diethyl piperidine-1,4,4-tricarboxylate (848070-26-8) → tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate (374794-84-0)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; toluene; at 60 ℃; for 16h; Heating / reflux;

Reference yield: 61.4%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate (374794-84-0)

Guidance literature:

formaldehyd; tert butyl 4-formylpiperidine-1-carboxylate; With potassium carbonate; In methanol; water; at 0 ℃; for 18h;

With methanol; sodium tetrahydroborate; at 0 - 20 ℃;

Reference yield: 30.0%

→ tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate (374794-84-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

upstream raw materials:

1-(tert-butyl) 4,4-diethyl piperidine-1,4,4-tricarboxylate

(4-hydroxymethylpiperidin-4-yl)methanol hydrochloride

di-tert-butyl dicarbonate

4-carbethoxypiperidine

Downstream raw materials:

C₁₅H₁₉NO₃

2-oxa-7-azaspiro[3,5]nonane acetic acid salt

2-oxa-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

C₂HF₃O₂*C₇H₁₃NO

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