Technology Process of 1,4,4-Piperidinetricarboxylic acid, 1-(1,1-dimethylethyl) 4,4-diethyl ester
There total 4 articles about 1,4,4-Piperidinetricarboxylic acid, 1-(1,1-dimethylethyl) 4,4-diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 - -35 ℃;
for 1.3h;
Inert atmosphere;
chloroformic acid ethyl ester;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
- Guidance literature:
-
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
chloroformic acid ethyl ester;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice
2.1: lithium diisopropyl amide / tetrahydrofuran / 1.3 h / -78 - -35 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
With
triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran;
