1-(2-Hydroxyethyl)cyclopentanol

Base Information

• Chemical Name: 1-(2-Hydroxyethyl)cyclopentanol
• CAS No.: 73089-93-7
• Molecular Formula: C7H14O2
• Molecular Weight: 130.187
• Hs Code.: 2906199090
• DSSTox Substance ID: DTXSID40555923
• Nikkaji Number: J861.865H
• Wikidata: Q72483638
• Mol file: 73089-93-7.mol

Synonyms:1-(2-Hydroxyethyl)cyclopentanol;73089-93-7;1-(2-hydroxyethyl)cyclopentan-1-ol;SCHEMBL287854;DTXSID40555923;QGMKCAZXZBYWCH-UHFFFAOYSA-N;AKOS015950473;SB84181;CS-0363392;J-503023

Chemical Property of 1-(2-Hydroxyethyl)cyclopentanol

Chemical Property:

• Refractive Index: 1.4815
• Boiling Point: 256.01 °C at 760 mmHg
• PKA: 14.90±0.20(Predicted)
• Flash Point: 123.372 °C
• PSA: 40.46000
• Density: 1.092 g/cm³
• LogP: 0.67390
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 130.099379685
• Heavy Atom Count: 9
• Complexity: 84.9

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2-Hydroxyethyl)cyclopentanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)(CCO)O

Technology Process of 1-(2-Hydroxyethyl)cyclopentanol

There total 11 articles about 1-(2-Hydroxyethyl)cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-(1-hydroxycyclopentyl)acetate (13278-09-6) → 1-(2'-hydroxyethyl)-1-cyclopentanol (73089-93-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 85.0%

ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0) → 1-(2'-hydroxyethyl)-1-cyclopentanol (73089-93-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

Reference yield: 64.0%

1,4-dibromo-butane (110-52-1) + β-Propiolactone (57-57-8) → 1-(2'-hydroxyethyl)-1-cyclopentanol (73089-93-7)

Guidance literature:

1,4-dibromo-butane; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

β-Propiolactone; In tetrahydrofuran; at -40 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00580

upstream raw materials:

2-(1-hydroxycyclopentyl)acetic acid

β-Propiolactone

1,4-bis(bromomagnesium)butane

ethyl 2-(1-hydroxycyclopentyl)acetate

Downstream raw materials:

1-(2-Phenylsulfanyl-ethyl)-cyclopentanol

1-(2-Benzenesulfonyl-ethyl)-cyclopentanol

1-<2-(phenylsulfonyl)ethyl>-1-<(triethylsilyl)oxy>cyclopentane

26,27-trimethylene-1,25-dihydroxyvitamin D₃