Ethyl 2-(1-hydroxycyclopentyl)acetate

Base Information

• Chemical Name: Ethyl 2-(1-hydroxycyclopentyl)acetate
• CAS No.: 3197-76-0
• Molecular Formula: C9H16O3
• Molecular Weight: 172.224
• Hs Code.: 2918199090
• European Community (EC) Number: 894-702-1
• DSSTox Substance ID: DTXSID40473052
• Nikkaji Number: J756.866E
• Wikidata: Q82302229
• Mol file: 3197-76-0.mol

Synonyms:Ethyl 2-(1-hydroxycyclopentyl)acetate;3197-76-0;ethyl (1-hydroxycyclopentyl)acetate;SCHEMBL8264963;DTXSID40473052;ethyl(1-hydroxycyclopentyl)acetate;FFQXMPGGIREDHJ-UHFFFAOYSA-N;AKOS011682292;CS-0258531;E89601;EN300-704297;(1-Hydroxy-cyclopentyl)-acetic acid ethyl ester;2-[[(4-Fluorophenyl)sulfonyl]amino]-2-phenylaceticacid

Chemical Property of Ethyl 2-(1-hydroxycyclopentyl)acetate

Chemical Property:

• PSA: 46.53000
• LogP: 1.24470
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 172.109944368
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

98%min ^*data from raw suppliers

(1-HYDROXY-CYCLOPENTYL)-ACETIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1(CCCC1)O

Technology Process of Ethyl 2-(1-hydroxycyclopentyl)acetate

There total 10 articles about Ethyl 2-(1-hydroxycyclopentyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl bromoacetate (105-36-2) + cyclopentanone (120-92-3) → ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0)

Guidance literature:

ethyl bromoacetate; With chloro-trimethyl-silane; zinc; In diethyl ether; at 20 ℃; for 2h; Reflux;

cyclopentanone; In diethyl ether; at 19 - 21 ℃; for 1h;

With ammonia; In diethyl ether; water; Cooling with ice;

DOI:10.1016/j.bmc.2011.12.046

Reference yield: 94.0%

ethyl bromozincacetate;THF + cyclopentanone (120-92-3) → ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0)

Guidance literature:

ethyl bromozincacetate;THF; cyclopentanone; In tetrahydrofuran; at 0 - 25 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 90.0%

ethyl acetate (141-78-6) + cyclopentanone (120-92-3) → ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0)

Guidance literature:

ethyl acetate; With lithium diisopropyl amide;

cyclopentanone;

DOI:10.1021/ja9716160

upstream raw materials:

Cyclopentene oxide

ethyl bromoacetate

cyclopentanone

ethanol

Downstream raw materials:

1-Hydroxycyclopentylacetohydrazid

ethyl cyclopentylideneacetate

ethyl cyclopenten-1-ylacetate

2-(1-hydroxycyclopentyl)acetic acid