Ethyl (1-hydroxycyclopentyl)acetate

Base Information

• Chemical Name: Ethyl (1-hydroxycyclopentyl)acetate
• CAS No.: 3197-76-0
• Molecular Formula: C9H16O3
• Molecular Weight: 172.224
• Hs Code.: 2918199090
• Mol file: 3197-76-0.mol

Synonyms:Cyclopentaneacetic acid,1-hydroxy-,ethyl ester;

Chemical Property of Ethyl (1-hydroxycyclopentyl)acetate

Chemical Property:

• PSA: 46.53000
• LogP: 1.24470

Purity/Quality:

98%min ^*data from raw suppliers

(1-HYDROXY-CYCLOPENTYL)-ACETIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl (1-hydroxycyclopentyl)acetate

There total 10 articles about Ethyl (1-hydroxycyclopentyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl bromoacetate (105-36-2) + cyclopentanone (120-92-3) → ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0)

Guidance literature:

ethyl bromoacetate; With chloro-trimethyl-silane; zinc; In diethyl ether; at 20 ℃; for 2h; Reflux;

cyclopentanone; In diethyl ether; at 19 - 21 ℃; for 1h;

With ammonia; In diethyl ether; water; Cooling with ice;

DOI:10.1016/j.bmc.2011.12.046

Reference yield: 94.0%

ethyl bromozincacetate;THF + cyclopentanone (120-92-3) → ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0)

Guidance literature:

ethyl bromozincacetate;THF; cyclopentanone; In tetrahydrofuran; at 0 - 25 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 90.0%

ethyl acetate (141-78-6) + cyclopentanone (120-92-3) → ethyl 2-(1-hydroxycyclopentyl)acetate (3197-76-0)

Guidance literature:

ethyl acetate; With lithium diisopropyl amide;

cyclopentanone;

DOI:10.1021/ja9716160

upstream raw materials:

Cyclopentene oxide

ethyl bromoacetate

cyclopentanone

ethanol

Downstream raw materials:

1-Hydroxycyclopentylacetohydrazid

ethyl cyclopentylideneacetate

ethyl cyclopenten-1-ylacetate

2-(1-hydroxycyclopentyl)acetic acid

Refernces

• 1、 Guan, Zhaobing,Ding, Manman,Sun, Yao,Yu, Sisi,Zhang, Ao,Xia, Shuguang,Hu, Xiaosong,Lin, Yawei. "The synthesis of two long-chain N-hydroxy amino coumarin compounds and their applications in the analysis of aldehydes". . p. 19707 - 19716. Retrieved 2017.
• 2、 -. "COMPOUND, RESIN, RESIST COMPOSITION AND PRODUCTION METHOD OF RESIST PATTERN". Paragraph 0201. . Retrieved 2020/10/27.