(S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

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Chemical Name:(S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide
CAS No.:78221-62-2
Molecular Formula:BrH*C₂₆H₄₁N₅O₄S
Molecular Weight:600.621
Hs Code.:

(S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

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Chemical Property of (S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

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Technology Process of (S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

There total 5 articles about (S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78221-61-1
benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

: 78221-62-2
(S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

Guidance literature:: With hydrogen bromide; In acetic acid; for 0.5h; Ambient temperature;
DOI:10.1135/cccc19810286

Reference yield:

: 2002-44-0
melanostatin

: 78221-62-2
(S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

2: HBr / acetic acid / 0.5 h / Ambient temperature

With hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19810286

Reference yield:

: 78221-55-3
S-(2,4,6-trimethylbenzyl)-L-cysteine

: 78221-62-2
(S)-1-[(R)-2-Amino-3-(2,4,6-trimethyl-benzylsulfanyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / NaOH / H₂O / 0.5 h / Ambient temperature

2: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

3: HBr / acetic acid / 0.5 h / Ambient temperature

With sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19810286