C₄₉H₅₄Cl₆FNO₁₈

Base Information

Chemical Name:C₄₉H₅₄Cl₆FNO₁₈
CAS No.:143527-60-0
Molecular Formula:C₄₉H₅₄Cl₆FNO₁₈
Molecular Weight:1176.68
Hs Code.:

C<sub>49</sub>H<sub>54</sub>Cl<sub>6</sub>FNO<sub>18</sub>

Synonyms:

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Chemical Property of C₄₉H₅₄Cl₆FNO₁₈

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Technology Process of C₄₉H₅₄Cl₆FNO₁₈

There total 10 articles about C₄₉H₅₄Cl₆FNO₁₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154306-84-0
methyl (2R,3S)-2-hydroxy-3-[(S)-1-phenyl]ethylamino-3-(4-fluorophenyl)propionate

: 143527-60-0
C₄₉H₅₄Cl₆FNO₁₈

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

2: Na₂CO₃ / CH₂Cl₂ / 72 h / 20 °C

3: 78 percent / pyridinium paratoluenesulfonate / toluene / 80 °C

4: 92 percent / LiOH / ethanol; H₂O / 2 h / 20 °C

5: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C

6: HCOOH / 4 h / 20 °C

7: NaHCO₃ / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; formic acid; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; sodium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61724-0

Reference yield:

: 154306-83-9
(3R,4S)-3-hydroxy-4-(4-fluorophenyl)-1-[(S)-1-phenyl]ethyl-2-azetidinone

: 143527-60-0
C₄₉H₅₄Cl₆FNO₁₈

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / hydrogen chloride gas / 2.5 h / 40 °C

2: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

3: Na₂CO₃ / CH₂Cl₂ / 72 h / 20 °C

4: 78 percent / pyridinium paratoluenesulfonate / toluene / 80 °C

5: 92 percent / LiOH / ethanol; H₂O / 2 h / 20 °C

6: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C

7: HCOOH / 4 h / 20 °C

8: NaHCO₃ / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; lithium hydroxide; formic acid; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; sodium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61724-0

Reference yield:

: Acetic acid (2R,3S)-2-(4-fluoro-phenyl)-4-oxo-1-((S)-1-phenyl-ethyl)-azetidin-3-yl ester

: 143527-60-0
C₄₉H₅₄Cl₆FNO₁₈

Guidance literature:: Multi-step reaction with 9 steps

1: 51 percent / potassium hydroxide 1M H₂O / tetrahydrofuran / 1 h / 0 °C

2: 84 percent / hydrogen chloride gas / 2.5 h / 40 °C

3: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

4: Na₂CO₃ / CH₂Cl₂ / 72 h / 20 °C

5: 78 percent / pyridinium paratoluenesulfonate / toluene / 80 °C

6: 92 percent / LiOH / ethanol; H₂O / 2 h / 20 °C

7: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C

8: HCOOH / 4 h / 20 °C

9: NaHCO₃ / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; potassium hydroxide; lithium hydroxide; formic acid; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; sodium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61724-0