6-Fluorohexahydro-1H-1,4-diazepine

Base Information

• Chemical Name: 6-Fluorohexahydro-1H-1,4-diazepine
• CAS No.: 123187-94-0
• Molecular Formula: C5H11FN2
• Molecular Weight: 118
• Mol file: 123187-94-0.mol

Synonyms:6-Fluorohexahydro-1H-1,4-diazepine;6-Fluoro-1,4-diazepane

Chemical Property of 6-Fluorohexahydro-1H-1,4-diazepine

Chemical Property:

• Boiling Point: 174℃
• Flash Point: 59℃
• PSA: 24.06000
• Density: 1.03
• LogP: 0.17490

Purity/Quality:

99% ^*data from raw suppliers

6-Fluoro-1,4-diazepane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluorohexahydro-1H-1,4-diazepine

There total 2 articles about 6-Fluorohexahydro-1H-1,4-diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,4-dibenzyl-6-fluoroperhydro-1,4-diazepine (1012784-40-5) → 6-fluoro-1H-1,4-diazepine (123187-94-0)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

1,4-dibenzyl-1,4-diazepan-6-ol (389062-84-4) → 6-fluoro-1H-1,4-diazepine (123187-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 20 °C

With diethylamino-sulfur trifluoride; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; dichloromethane;

upstream raw materials:

1,4-dibenzyl-1,4-diazepan-6-ol

1,4-dibenzyl-6-fluoroperhydro-1,4-diazepine