SPhos Pd G1, Methyl t-Butyl Ether Adduct

Base Information

• Chemical Name: SPhos Pd G1, Methyl t-Butyl Ether Adduct
• CAS No.: 1028206-58-7
• Molecular Formula: C34H45ClNO2PPd
• Molecular Weight: 760.72200

Synonyms:[PtCl2(N,N-dimethylethylenediamine)]; cis-dichloro(N,N-dimethylethylenediamine)platinum(II); chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II); cis-(N,N-dimethyl-ethylenediamine)dichloroplatinum(II); (SP-4-3)-dichlorido(N,Ndimethylethane-1,2-diamine)platinum(II); Platinum (II),dichloro(N,N-dimethylethylenediammine); [Pt2(N,N-dimethylethylenediamine)Cl2]; Dichloro(N,N-dimethylethylenediammine)platinum(II); 查看更多英文别名 收起

Chemical Property of SPhos Pd G1, Methyl t-Butyl Ether Adduct

Chemical Property:

• Melting Point: 176℃
• PSA: 67.30000
• LogP: 7.46980
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Chloro(2-dicyclohexylphosphino-2'',6''-dimethoxy-1,1''-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Chloro(2-dicyclohexylphosphino-2'',6''-dimethoxy-1,1''-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) has been used as catalyst in, the studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential; ?Biaryl Phosphine Based Pd(II) Amido Complexes: The Effect of Ligand Structure on Reductive Elimination Application Guide for Palladium Catalyzed Cross-Coupling ReactionsCatalyst for C-N bond forming reaction.

Technology Process of SPhos Pd G1, Methyl t-Butyl Ether Adduct

There total 4 articles about SPhos Pd G1, Methyl t-Butyl Ether Adduct which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane (657408-07-6) + (N,N,N',N'-tetramethylethylenediamine)dimethylpalladium(II) + 2-(2-chlorophenyl)ethanamine (13078-80-3) → chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) (1028206-58-7)

Guidance literature:

In further solvent(s); treatment of palladium compd. with chlorobenzene deriv. and phosphine deriv. in methyl tert-butyl ether at 55°C; recrystn.;

DOI:10.1021/ja801137k

Reference yield: 85.0%

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane (657408-07-6) + 2-(2-chlorophenyl)ethanamine (13078-80-3) + N,N,N',N'-tetramethylethylenediamine palladium(II) chloride (14267-08-4) + methyllithium (917-54-4) → chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) (1028206-58-7)

Guidance literature:

In further solvent(s); treatment of palladium compd. with methyllithium in methyl tert-butyl ether at 0°C, treatment with chlorobenzene deriv. and phosphine deriv. in methyl tert-butyl ether at 55°C; recrystn.;

DOI:10.1021/ja801137k

Reference yield: 85.0%

[Pd2(C,N-C6H4CH2CH2NH2-2)2(μ-Cl)2] (1323952-89-1) + 2-dicyclohexylphosphino-2',6'-dimethoxyphenyl (1356823-31-8,657408-07-6) → [PdCl(C,N-2-(phenyl)ethylamine(-1H))(2-dicyclohexylphosphino-2',6'-dimethoxyphenyl)] (1028206-58-7)

Guidance literature:

In dichloromethane; addn. of (C6H11)2PC6H4C6H3(OMe)2 to suspn. of Pd2(C6H4CH2CH2NH2)Cl2 in CH2Cl2, stirring for 0.5 h; filtration, removal of solvent from filtrate, vigorous stirring in pentane, filtration, washing with pentane, drying in air; elem. anal.;

DOI:10.1021/om200464s

upstream raw materials:

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane

2-(2-chlorophenyl)ethanamine

N,N,N',N'-tetramethylethylenediamine palladium(II) chloride

methyllithium

Downstream raw materials:

(Cy₂PC₆H₄C₆H₃(OMe)2)Pd

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