2-(4-(Benzyloxy)-3-fluorophenyl)propanoic acid

Base Information

Chemical Name:2-(4-(Benzyloxy)-3-fluorophenyl)propanoic acid
CAS No.:127437-34-7
Molecular Formula:C₁₆H₁₅FO₃
Molecular Weight:274.292
Hs Code.:
DSSTox Substance ID:DTXSID90874777

Synonyms:2-(4-(BENZYLOXY)-3-FLUOROPHENYL)PROPANOIC ACID;DTXSID90874777;AKOS024405152;127437-34-7;PROPIONIC ACID,2-(3-FLUORO-4-PHENYLMETHOXY)PHENY

Suppliers and Price of 2-(4-(Benzyloxy)-3-fluorophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(Benzyloxy)-3-fluorophenyl)propanoic acid

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:274.10052250
Heavy Atom Count:20
Complexity:315

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)OCC2=CC=CC=C2)F)C(=O)O

Technology Process of 2-(4-(Benzyloxy)-3-fluorophenyl)propanoic acid

There total 11 articles about 2-(4-(Benzyloxy)-3-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1391847-86-1
C₂₃H₂₁FO₃

: 127437-34-7
2-(3-fluoro-4-benzyloxyphenyl)propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2012.06.059

Reference yield:

: 2-(4-Benzyloxy-3-fluoro-phenyl)-propionic acid methyl ester

: 127437-34-7
2-(3-fluoro-4-benzyloxyphenyl)propanoic acid

Guidance literature:: With potassium hydroxide; water; In ethanol; for 8h; Yield given; Heating;

Reference yield:

: 321-28-8
1-fluoro-2-methoxybenzene

: 127437-34-7
2-(3-fluoro-4-benzyloxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: HCl (gas), ZnCl₂ / acetic acid / 8 h / Heating

2: 90 percent / dimethylsulfoxide / 3 h / 40 - 45 °C

3: NaOEt / ethanol / 95 - 125 °C

4: NaOEt / ethanol / 1.) 40 deg C, 3 h, 2.) reflux, 3 h

5: H₂O, KOH / ethanol / 10 h / Heating

6: AlCl₃ / toluene / 5 h / Heating

7: HCl / Heating

8: 1.) NaOMe / 1.) MeOH, 20 deg C, 15 min, 2.) DMSO, 100 deg C, 6 h

9: H₂O, KOH / ethanol / 8 h / Heating

With hydrogenchloride; potassium hydroxide; aluminium trichloride; water; sodium methylate; sodium ethanolate; zinc(II) chloride; In ethanol; acetic acid; dimethyl sulfoxide; toluene;