Azido-PEG4-CH2CO2H

Base Information

• Chemical Name: Azido-PEG4-CH2CO2H
• CAS No.: 201467-81-4
• Molecular Formula: C10H19N3O6
• Molecular Weight: 277.277
• European Community (EC) Number: 694-381-6
• Mol file: 201467-81-4.mol

Synonyms:201467-81-4;Azido-PEG4-CH2CO2H;N3-PEG4-CH2COOH;N33-TEG-COOH;14-azido-3,6,9,12-tetraoxatetradecanoic acid;N3-TEG-COOH;Acetic acid, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-;14-azido-3,6,9,12-tetraoxatetradecan-1-oic acid;14-Azido-3,6,9,12-tetraoxatetradecanoic acid;AZIDO-PEG4-CH2COOH;SCHEMBL13485723;YHTABJLSZLHRFV-UHFFFAOYSA-N;2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]acetic Acid;MFCD20134123;AKOS037653334;N33-TEG-COOH (N3-TEG-COOH);BP-22301;HY-108370;CS-0028493;14azido-3, 6,9,12-tetraoxatetradecanoic acid;D84637;14-Azido-3,6,9,12-tetraoxa-1-tetradecanoic acid;R14-0273;2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanoic acid

Chemical Property of Azido-PEG4-CH2CO2H

Chemical Property:

• Flash Point: -33℃
• PSA: 123.97000
• Density: 0.750-0.850 g/mL at 20 °C
• LogP: -0.09954
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 14
• Exact Mass: 277.12738533
• Heavy Atom Count: 19
• Complexity: 270

Purity/Quality:

98%,99%, ^*data from raw suppliers

14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution ~0.5 M in tert-butyl methyl ether, ≥90% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-38
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCOCCOCC(=O)O)N=[N+]=[N-]
• Uses: Azido-PEG4-CH2CO2H is a useful research chemical.
• Description: Azido-PEG4-CH2CO2H is a very popular click chemistry linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU).

Technology Process of Azido-PEG4-CH2CO2H

There total 12 articles about Azido-PEG4-CH2CO2H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]acetate (256397-65-6) → 14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid (201467-81-4)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; Inert atmosphere;

DOI:10.3762/bjoc.12.130

Reference yield: 97.0%

14-azido-3,6,9,12-tetraoxatetradcyl-1-tert-butyl carboxyl → 14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid (201467-81-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃;

Reference yield: 92.0%

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol (86770-67-4) + bromoacetic acid (79-08-3) → 14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid (201467-81-4)

Guidance literature:

With sodium hydride; In dichloromethane;

upstream raw materials:

bromoacetic acid,potassium salt

ethyl 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetate

methanesulfonyl chloride

ethyl 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]acetate

Downstream raw materials:

N₃-TEG-NHBoc

14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid

C₁₆H₂₈N₄O₉

C₆₁H₈₀N₄O₃₁