Amino-PEG4-CH2CO2H

Base Information

• Chemical Name: Amino-PEG4-CH2CO2H
• CAS No.: 195071-49-9
• Molecular Formula: C10H21NO6
• Molecular Weight: 251.28
• Hs Code.: 2942000090
• DSSTox Substance ID: DTXSID10594283
• Wikidata: Q82489081
• Mol file: 195071-49-9.mol

Synonyms:195071-49-9;Amino-PEG4-CH2CO2H;Amino-PEG4-CH2COOH;H2N-PEG4-CH2COOH;Amino-PEG4-acetic acid;14-amino-3,6,9,12-tetraoxatetradecanoic acid;14-Amino-3,6,9,12-tetraoxatetradecan-1-oic acid;3,6,9,12-Tetraoxatetradecanoic acid, 14-amino-;MFCD27977508;Amine-PEG4-CH2COOH;NH2-PEG4-CH2COOH;SCHEMBL1170690;DTXSID10594283;WLZ3781;2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetic acid;VHA07149;AKOS028109928;s10597;BP-22098;BS-25456;SY272977;HY-130524;CS-0108846;14-Amino-3,6,9,12-tetraoxatetradecan-1-oicacid;(2-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid

Chemical Property of Amino-PEG4-CH2CO2H

Chemical Property:

• Boiling Point: 397.6±32.0 °C(Predicted)
• PKA: 3.39±0.10(Predicted)
• PSA: 100.24000
• Density: 1.156±0.06 g/cm3(Predicted)
• LogP: -0.20360
• XLogP3: -4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 13
• Exact Mass: 251.13688739
• Heavy Atom Count: 17
• Complexity: 178

Purity/Quality:

98%,99%, ^*data from raw suppliers

H2N-PEG4-CH2COOH min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCOCCOCC(=O)O)N
• Description: Amino-PEG4-CH2CO2H is a PEG linker containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Technology Process of Amino-PEG4-CH2CO2H

There total 4 articles about Amino-PEG4-CH2CO2H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid (201467-81-4) → 14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid (195071-49-9,139729-28-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol;

Reference yield:

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5) → 14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid (195071-49-9,139729-28-5)

Guidance literature:

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol; With Jones reagent;

With palladium on activated charcoal; hydrogen;

Reference yield:

Pentaethylene glycol (4792-15-8) → 14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid (195071-49-9,139729-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran

2: sodium azide / N,N-dimethyl-formamide / Heating

3: Jones reagent

With Jones reagent; sodium azide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid

Pentaethylene glycol

2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol

Downstream raw materials:

[2-(2-{2-[2-((9H-fluoren-9-yl-methoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid

14-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradecanoic acid