Thiazovivin

Base Information

Chemical Name:Thiazovivin
CAS No.:1226056-71-8
Molecular Formula:C15H13N5OS
Molecular Weight:311.367
Hs Code.:2934100090
Mol file:1226056-71-8.mol

Synonyms:N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide;Thiazovivin;N-(Phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide

Suppliers and Price of Thiazovivin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Thiazovivin
10mg
$ 799.00

Usbiological
Thiazovivin
1mg
$ 360.00

TRC
Thiazovivin
25mg
$ 340.00

TRC
Thiazovivin
10mg
$ 145.00

Tocris
Thiazovivin ≥98%(HPLC)
10
$ 450.00

Sigma-Aldrich
Thiazovivin ≥98% (HPLC)
5mg
$ 124.00

Sigma-Aldrich
Thiazovivin ≥98% (HPLC)
25mg
$ 399.00

Medical Isotopes, Inc.
Thiazovivin
100 mg
$ 2075.00

Medical Isotopes, Inc.
Thiazovivin
25 mg
$ 825.00

Matrix Scientific
N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide 95+%
1g
$ 1650.00

Total 40 raw suppliers

Chemical Property of Thiazovivin

Chemical Property:

PSA：108.04000
Density:1.38 g/cm³
LogP:3.07060
Storage Temp.:Store at -20°C
Solubility.:DMSO: soluble20mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

Thiazovivin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Description Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. Thiazovivin (1226056-71-8) dramatically improves (200-fold) the efficiency of induced pluripotent stem cell generation from human fibroblasts.1 Induces direct conversion of porcine embryonic fibroblasts into adipocytes.2?Cell permeable.
Uses A compound that improves the survival of human embryonic stem cells (hESCs) upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901 (P217450), Thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.

Technology Process of Thiazovivin

There total 3 articles about Thiazovivin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8
pyrimidin-4-amine

: 1449218-23-8
N-benzyl-2-bromothiazol-4-carboxamide

: 1226056-71-8
thiazovivin

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 140 ℃; for 3h;
DOI:10.1080/00397911.2012.745567

Reference yield: 52.1%

: C₃₁H₃₄N₇O₄S⁽¹⁺⁾*F₆P^(1-)

: 1226056-71-8
thiazovivin

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: C₁₅H₁₂N₅OPolS

: 1226056-71-8
thiazovivin

Guidance literature:: With water; trifluoroacetic acid; In dichloromethane; for 2h; polystyrene resin (PAL) Product distribution / selectivity;