3-m-nitrobenzoyl butyric acid

Base Information

• Chemical Name: 3-m-nitrobenzoyl butyric acid
• CAS No.: 42075-28-5
• Molecular Formula: C₁₁H₁₁NO₅
• Molecular Weight: 237.212
• Mol file: 42075-28-5.mol

Synonyms:

Chemical Property of 3-m-nitrobenzoyl butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-m-nitrobenzoyl butyric acid

There total 4 articles about 3-m-nitrobenzoyl butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-nitropropiophenone (17408-16-1) → 3-m-nitrobenzoyl butyric acid (42075-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / Br₂ / acetic acid

2.1: NaH / dimethylformamide / 20 °C

2.2: dimethylformamide / 4 h / 110 °C

3.1: aq. HCl / 6 h / Heating

With hydrogenchloride; bromine; sodium hydride; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm030776l

Reference yield:

2-bromo-1-(3-nitrophenyl)propan-1-one (1205-36-3) → 3-m-nitrobenzoyl butyric acid (42075-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 20 °C

1.2: dimethylformamide / 4 h / 110 °C

2.1: aq. HCl / 6 h / Heating

With hydrogenchloride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm030776l

Reference yield:

2-[1-methyl-2-(3-nitro-phenyl)-2-oxo-ethyl]-malonic acid diethyl ester → 3-m-nitrobenzoyl butyric acid (42075-28-5)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1021/jm030776l

upstream raw materials:

3'-nitropropiophenone

2-bromo-1-(3-nitrophenyl)propan-1-one

Downstream raw materials:

5-methyl-6-(3-nitrophenyl)-4,5-dihydro-2H-pyridazin-3-one

6-(3-aminophenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Refernces

• 1、 -. "Method for treating anxiety in mammals". . . Retrieved 2008/06/13.
• 2、 Curran,Ross. "6 Phenyl 4,5 dihydro 3(2H) pyridazinones. A series of hypotensive agents". . p. 273 - 281. Retrieved 2007/10/05.