[(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester
• CAS No.: 98376-27-3
• Molecular Formula: C₄₂H₃₆FN₂O₆P
• Molecular Weight: 714.73

Synonyms:

Chemical Property of [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

There total 4 articles about [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4S)-4-(3-Bromo-2-oxo-propyl)-3-(1-fluoro-ethyl)-azetidin-2-one (98376-23-9,99437-03-3) → [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (98376-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 2) NaHCO₃ / 1) CH₂Cl₂; 2) H₂O

2: 60 percent / toluene / Heating

With sodium hydrogencarbonate; In toluene;

DOI:10.1016/S0040-4039(00)94906-2

Reference yield:

benzaldehyde (100-52-7) → [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (98376-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / toluene / Heating

In toluene;

DOI:10.1016/S0040-4039(00)94906-2

Reference yield:

(3S,4S)-3-(1-Fluoro-ethyl)-4-[2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-azetidin-2-one (98376-24-0,98463-14-0) → [(3R,4R)-3-(1-Fluoro-ethyl)-2-oxo-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (98376-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / toluene / Heating

In toluene;

DOI:10.1016/S0040-4039(00)94906-2

upstream raw materials:

p-nitrobenzyl glyoxylate monohydrate

(3S,4S)-3-(1-Fluoro-ethyl)-4-((E)-2-oxo-4-phenyl-but-3-enyl)-azetidin-2-one

triphenylphosphine

(3S,4S)-4-(3-Bromo-2-oxo-propyl)-3-(1-fluoro-ethyl)-azetidin-2-one

Downstream raw materials:

Potassium; (2R,3S,5R,6R)-6-(1-fluoro-ethyl)-7-oxo-3-phenethyl-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Potassium; (2S,3R,5R,6R)-6-(1-fluoro-ethyl)-7-oxo-3-phenethyl-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

(5R,6R)-6-(1-Fluoro-ethyl)-7-oxo-3-((E)-styryl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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