(1s)-1-(4-fluorophenyl)butylaMine-hcl

Base Information

• Chemical Name: (1s)-1-(4-fluorophenyl)butylaMine-hcl
• CAS No.: 321840-52-2
• Molecular Formula: C10H14FN
• Molecular Weight: 167.2232632
• Hs Code.: 2921499090
• Mol file: 321840-52-2.mol

Synonyms:(1s)-1-(4-fluorophenyl)butylaMine-hcl;(S)-1-(4-Fluorophenyl)butan-1-aMine

Chemical Property of (1s)-1-(4-fluorophenyl)butylaMine-hcl

Chemical Property:

• Boiling Point: 226.2±15.0 °C(Predicted)
• PKA: 9.25±0.10(Predicted)
• PSA: 26.02000
• Density: 1.020±0.06 g/cm3(Predicted)
• LogP: 3.32590
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(S)-1-(4-Fluorophenyl)butan-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1s)-1-(4-fluorophenyl)butylaMine-hcl

There total 6 articles about (1s)-1-(4-fluorophenyl)butylaMine-hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2R)-2-{[(1R)-1-(4-fluorophenyl)-3-butenyl]amino}-2-phenylethanamide (698378-00-6) → (1R)-1-butyl-1-(4-fluorophenyl)amine (321839-98-9,321840-52-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; acetic acid; isopropyl alcohol; at 20 ℃; for 120h;

DOI:10.1002/ejoc.200300662

Reference yield: 61.0%

1-(4-fluoro-phenyl)-butan-1-one O-benzyl-oxime → (S)-1-(4-fluorophenyl)butan-1-amine (321839-98-9,321840-52-2)

Guidance literature:

With borane; 1,1-diphenyl-L-valinol; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0957-4166(01)00358-5

Reference yield: 50.0%

1-(4-fluorophenyl)butan-1-one (582-83-2) → α-propyl-4-fluorobenzylamine (321839-98-9,321840-52-2)

Guidance literature:

1-(4-fluorophenyl)butan-1-one; With ammonium acetate; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 12h;

upstream raw materials:

(2R)-2-{[(1R)-1-(4-fluorophenyl)-3-butenyl]amino}-2-phenylethanamide

4-fluorobenzaldehyde

(2R)-2-{[(E)-(4-fluorophenyl)methylidene]amino}-2-phenylacetamide

1-(4-fluorophenyl)butan-1-one

Downstream raw materials:

N-[1-(4-fluorophenyl)butyl]-2-(2,4-dichlorophenoxy)propanamide

Refernces

• 1、 Dalmolen, Jan,Van Der Sluis, Marcel,Nieuwenhuijzen, Jose W.,Meetsma, Auke,De Lange, Ben,Kaptein, Bernard,Kellogg, Richard M.,Broxterman, Quirinus B.. "Synthesis of enantiopure 1-aryl-1-butylamines and 1-aryl-3-butenylamines by diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide". . p. 1544 - 1557. Retrieved 2007/10/03.