Welcome to LookChem.com Sign In|Join Free

CAS

  • or
1-(4-FLUORO-PHENYL)-BUTAN-1-ONE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a fluorophenyl group attached to a butanone moiety, which contributes to its unique chemical properties and reactivity.

582-83-2 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 582-83-2 Structure
  • Basic information

    1. Product Name: 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE
    2. Synonyms: 1-Butanone, 1-(4-fluorophenyl)-;Butyrophenone, 4'-fluoro-;p-Fluorobutyrophenone;4'-FLUOROBUTYROPHENONE;1-(4-FLUORO-PHENYL)-BUTAN-1-ONE;1-(4-Fluorophenyl)-1-butanone;p-Fluorophenylpropyl ketone;4'-Fluorobutyrophenone 98%
    3. CAS NO:582-83-2
    4. Molecular Formula: C10H11FO
    5. Molecular Weight: 166.19
    6. EINECS: 209-492-3
    7. Product Categories: N/A
    8. Mol File: 582-83-2.mol
  • Chemical Properties

    1. Melting Point: 38 °C
    2. Boiling Point: 102 °C
    3. Flash Point: 91.5 °C
    4. Appearance: /
    5. Density: 1.05 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. Water Solubility: Insoluble in water.
    10. CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE(582-83-2)
    12. EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE(582-83-2)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 582-83-2(Hazardous Substances Data)

582-83-2 Usage

Uses

Used in Pharmaceutical Industry:
1-(4-FLUORO-PHENYL)-BUTAN-1-ONE is used as a key intermediate in the synthesis of various 4'-fluorobutyrophenone derivatives, which are important in the development of pharmaceutical compounds. These derivatives include haloperidol, haloanisone, triperidol, methylperidide, haloperidide, and dipiperone, which have applications in the treatment of various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 582-83-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 582-83:
(5*5)+(4*8)+(3*2)+(2*8)+(1*3)=82
82 % 10 = 2
So 582-83-2 is a valid CAS Registry Number.

582-83-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H26034)  4'-Fluorobutyrophenone, 97%   

  • 582-83-2

  • 1g

  • 723.0CNY

  • Detail
  • Alfa Aesar

  • (H26034)  4'-Fluorobutyrophenone, 97%   

  • 582-83-2

  • 5g

  • 2744.0CNY

  • Detail

582-83-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-fluorophenyl)butan-1-one

1.2 Other means of identification

Product number -
Other names Butyrophenone,4'-fluoro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:582-83-2 SDS

582-83-2Relevant articles and documents

The pollen tube growth regulator (by machine translation)

-

Paragraph 0211-0213, (2020/11/03)

The pollen tube growth regulating agent [a]. (1) A compound represented by the general formula [a], a salt thereof, a solvate thereof selected from the group consisting of at least 1 kind, the pollen tube growth regulator. [Drawing] no (by machine translation)

Palladium-Catalyzed Carbonylative Coupling of Aryl Iodides with Alkyl Bromides: Efficient Synthesis of Alkyl Aryl Ketones

Peng, Jin-Bao,Chen, Bo,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng

supporting information, p. 4153 - 4160 (2018/09/21)

Alkyl aryl ketones are important structures with applications in many areas of chemistry. Hence, efficient procedures for their production are particularly attractive. In this communication, a general and efficient carbonylative cross-coupling of aryl iodides and unactivated alkyl bromides is presented. By using a simple palladium catalyst, a series of alkyl aryl ketones were synthesized in moderate to excellent yields from readily available alkyl and aryl halides in an In-Ex tube with formic acid as the CO source. In this study both primary and secondary alkyl bromides/iodides were suitable coupling partners. Additionally, this method can also be employed for the late-stage functionalization of complex natural products and polyfunctionalized molecules. (Figure presented.).

Dirhodium(ii)/P(t-Bu)3 catalyzed tandem reaction of α,β-unsaturated aldehydes with arylboronic acids

Ma, Ziling,Wang, Yuanhua

supporting information, p. 7470 - 7476 (2018/10/24)

Phosphine ligated dirhodium(ii) acetate is advocated as a catalyst for the synthesis of aryl alkyl ketones by the tandem reaction of α,β-unsaturated aromatic or aliphatic aldehydes with arylboronic acids. This tandem procedure included arylation followed by the isomerization reaction. This method exhibits good functional group tolerance and has a broad substrate scope. With the conjugated aldehydes, the one-step synthesis of γ,δ-unsaturated ketones was realized through this reaction. It is noteworthy that the length of the Rh-P bond is an important factor affecting catalytic reactions. The comparative analysis of the crystal structures of axially alkylphosphane and arylphosphane ligated dirhodium(ii) acetate revealed that the shorter Rh-P bond length favors the isomerization process as compared to the longer one. In addition, the dirhodium(ii) compound can be recovered after the completion of the reaction.

METALLOENZYME INHIBITOR COMPOUNDS

-

Page/Page column 159, (2018/09/28)

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Synthetic method of 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl) butanone

-

Paragraph 0009; 0093-0095, (2018/09/08)

The invention discloses a synthetic method of 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl) butanone. The synthetic method comprises the following steps: (1) carrying out a Friedel-Crafts reaction on chlorobenzene with n-butyryl chloride under the catalysis of aluminium trichloride to obtain a compound I; (2) carrying out a bromination reaction on the compound I with bromine under the action ofa catalytic oxidizing agent to obtain a compound II; (3) carrying out a substitution reaction on the compound II with dimethylamine to obtain a compound III; (4) carrying out a quaternization reactionon the compound III with benzyl chloride to obtain a compound IV; (5) carrying out a substitution reaction on the compound IV with morpholine under the action of a composite catalyst to obtain a compound V; and (6) carrying out a rearrangement reaction on the compound V under the action of an alkali so as to obtain the 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl) butanone. The synthetic methodprovided by the invention has the advantages of mild technological condition, simple operation, high selectivity and high total yield.

A new amino ketone photoinitiator and in UV - LED light curing system application (by machine translation)

-

Paragraph 0062; 0063, (2017/08/25)

The invention provides a method suitable for UV - LED light source setting new amino ketone photo initiator, can in long wave zone (365 - 395 nm) has stronger absorption, UV - LED light source is suitable for curing, has overcome the traditional cured high energy consumption, pollution and shortcomings. Electronic unlocalized is good, with strong intramolecular electron transfer performance and excellent photoelectric nature, in the long-wave region 365 nm - 395 nm range have strong absorption, is suitable for high-power UVLED ultraviolet light curing system, compared with the prior art such optical initiator has a considerable advantage. (by machine translation)

Alpha-amino acetophenone photoinitiator preparation method

-

Paragraph 0003; 0026, (2016/10/07)

The present invention relates to an alpha-amino acetophenone photoinitiator preparation method, particularly to a preparation method of 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl)butanone and 2-(4-methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)butanone. According to the present invention, 1-p-fluorophenyl-1-butanone is adopted as the raw material, and only the safe and cheap solvent is used in the whole method to conveniently prepare 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl)butanone and 2-(4-methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)butanone; and the method has characteristics of cheap and readily available raw materials, high yield, no requirement of intermediate purification, and continuous reaction without solvent replacement, and is the preparation method with characteristics of low cost, environmental protection and easy operation and suitable for industrialization.

Subtype-selective NMDA receptor ligands and the use thereof

-

, (2008/06/13)

The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neuro-degenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, Parkinson's disease, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

Bicyclic amide derivatives and their use as muscle relaxants

-

, (2008/06/13)

Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.

Bicyclic amide derivatives and their use as muscle relaxants

-

, (2008/06/13)

Novel compounds of formula (I) STR1 wherein R1, R2, R3 and R4 are each selected from hydrogen and fluoro and at least one and not more than two is fluoro; R5 is selected from hydrogen and C1 -C4 alkyl; R6 is selected from hydrogen, C1 -C4 ally and hydroxy; or R5 and R6 together with the ring carbon form a carbonyl group; R7 is selected from hydrogen and hydroxy, R8 and R9 are each selected from hydrogen, C1 -C4 alkyl and cyclo(C3 or C4) alkyl or together with the nitrogen form a morpholino group; and X is selected from a bond, methylene and --O-- and is always a bond or --O-- when any of R5, R6 and R7 is other than hydrogen and is always a bond when R5 and R6 together with the ring carbon form a carbonyl group; and their salts and solvates have a number of uses as central muscle relaxants. In particular, treatment of conditions associated with abnormally raised skeletal muscle tone. They are of special value in the relaxation of skeletal muscle in spastic, hypertonic and hyperkinetic conditions.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 582-83-2