Ethyl 6-chloro-4-methylpyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 6-chloro-4-methylpyridine-2-carboxylate
• CAS No.: 1122090-50-9
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.6342
• Hs Code.: 2933399090
• Mol file: 1122090-50-9.mol

Synonyms:2-Pyridinecarboxylic acid, 6-chloro-4-methyl-, ethyl ester;

Chemical Property of Ethyl 6-chloro-4-methylpyridine-2-carboxylate

Chemical Property:

• Boiling Point: 311.538 °C at 760 mmHg
• Flash Point: 142.213 °C
• PSA: 39.19000
• Density: 1.208 g/cm³
• LogP: 2.22010

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-chloro-4-methylpyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-chloro-4-methylpyridine-2-carboxylate

There total 3 articles about Ethyl 6-chloro-4-methylpyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

ethanol (64-17-5) + potassium 6-chloro-4-methylpyridine-2-carboxylic acid (1122090-48-5) → ethyl 6-chloro-4-methylpyridine-2-carboxylate (1122090-50-9)

Guidance literature:

With sulfuric acid; at 70 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm4014696

Reference yield:

6-chloro-4-methylpyridine-2-carboxylic acid (324028-95-7) + ethanol (64-17-5) → ethyl 6-chloro-4-methylpyridine-2-carboxylate (1122090-50-9)

Guidance literature:

With sulfuric acid; at 70 ℃; for 16h;

Reference yield:

6-chloro-4-methyl-2-vinylpyridine (1122090-46-3) → ethyl 6-chloro-4-methylpyridine-2-carboxylate (1122090-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium permanganate / water; acetone / 3 h / 20 - 40 °C

2.1: sulfuric acid / 18 h / 70 °C

2.2: pH 9

With potassium permanganate; sulfuric acid; In water; acetone;

upstream raw materials:

ethanol

potassium 6-chloro-4-methylpyridine-2-carboxylic acid

6-chloro-4-methyl-2-vinylpyridine

6-chloro-4-methylpyridine-2-carboxylic acid

Downstream raw materials:

2-chloro-6-(chloromethyl)-4-methyl-pyridine

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